oxidative stress 
|
a condition of increased oxidant production in cells characterized by the release of free radicals and resulting in cellular degeneration
oxidative stress can result from a lack of antioxidants or from an over abundance of free radicals
|
 |
causes of oxidative stress
toxic agents 
several drugs and toxins impose oxidative stress during their metabolism. carbon tetrachloride is one example
oxidative stress can be imposed in several ways like severe malnutrition which can deprive minerals (e.g., cu, mn, zn, se) and vitamins
disease and tissue injury
tissue damage by disease, trauma, poisons, and other causes usually leads to formation of increased amounts of putative "injury mediators", such as prostaglandins, leukotrienes, interleukins, interferons, and tumor necrosis factors (tnfs)
environmental air pollutants
the role of free radicals in the toxicity of o2 and of cigarette
smoke has already been discussed, but oxidative damage is frequently suggested to be involved in the deletingrious effects of o3 and no2.
|
|