Anti-anginal Drugs

Anti-Anginal Drugs
Angina pectoris
• Sudden, severe, pressing chest pain radiating to the neck, jaw, back, and arms.
• Coronary blood flow (insufficient to meet the O2 demands of the myocardium, leading to ischemia.
• Imbalance between O2 delivery & utilization result during exertion, from a spasm of the vascular smooth muscle, or from obstruction of blood vessels caused by atherosclerotic lesions.
As Definition: imbalance oxygen supply & requirement due to spasm or obstruction of coronary blood vessels leading to sudden severe pressing substernal chest pain.
Types of Angina Pectoris
1. Stable angina (during effort).
2. Unstable angina (at rest).
3. Vasospastic or variant angina (spastic).
4. Mixed form of Angina.
Stable angina (during effort).
• Most common (typical angina pectoris).
• Burning, heavy, or squeezing feeling in the chest.
• Reduction of coronary perfusion due to a fixed obstruction produced by coronary atherosclerosis.
• Relieved by rest or nitroglycerin (a vasodilator).
Unstable angina
• Between stable angina To myocardial infarction.
• The symptoms are not relieved by rest or nitroglycerin
Prinzmetal s or variant or vasospastic angina
• An uncommon pattern of episodic angina that occurs at rest
• Coronary artery spasm.
• Generally responds promptly to coronary vasodilators, such as Nitroglycerin & CCBs.