General Coronary Artery Disease and Stable Exertional Angina

Definition
? CAD is the leading cause of morbidity and mortality in Western
Society.
? Prevalence of CAD in the United States was 7.6% as of 2006.
? CAD was responsible for 35.3% of all U.S. deaths in 2005.
? An estimated 785,000 Americans will have a first MI and 470,000
will have a recurrent MI in 2009. Another 195,000 will have a
silent MI.
? Coronary artery disease (CAD) is most commonly defined as a
>50% luminal stenosis of any epicardial coronary artery.
? Chronic stable angina is the typical manifestation of ischemic
heart disease in nearly half of patients with CAD.
Epidemiology
Etiology
? CAD most commonly results from luminal obstruction by
atheromatous plaque.
? Other causes include congenital coronary abnormalities,
myocardial bridging, vasculitis, prior radiation therapy,
cocaine use, aortic stenosis, hypertrophic cardiomyopathy,
coronary vasospasm, spontaneous coronary dissection,
and syndrome X.

Definition
? CAD is the leading cause of morbidity and mortality in Western
Society.
? Prevalence of CAD in the United States was 7.6% as of 2006.
? CAD was responsible for 35.3% of all U.S. deaths in 2005.
? An estimated 785,000 Americans will have a first MI and 470,000
will have a recurrent MI in 2009. Another 195,000 will have a
silent MI.
? Coronary artery disease (CAD) is most commonly defined as a
>50% luminal stenosis of any epicardial coronary artery.
? Chronic stable angina is the typical manifestation of ischemic
heart disease in nearly half of patients with CAD.
Epidemiology
Etiology
? CAD most commonly results from luminal obstruction by
atheromatous plaque.
? Other causes include congenital coronary abnormalities,
myocardial bridging, vasculitis, prior radiation therapy,
cocaine use, aortic stenosis, hypertrophic cardiomyopathy,
coronary vasospasm, spontaneous coronary dissection,
and syndrome X.