chloride

referral department:
lab director:
jamal khalil jamal@biolab.jo
referral department officer:
ahmad shahin ahmad@biolab.jo
telephone: +962-6-464 11 55 ext: 102
fax: +962-6-464 09 00
for any query:
science development department:
nadia mousily nadia@biolab.jo
you can find all our practical information online @
www.biolab.jo
p.o. box 910909 amman
11118 jordan
address, contact numbers and key personnel……………………………………..
about us……………………………………………………………………………………..
our experience and professionalism………………………………………………….
our people………………………………………………………………………………….
our services………………………………………………………………………………...
our technologies……………………………………………………………………….....
practical information……………………………………………………………………...
our laboratories…………………………………………………………………………...
biolab partners with biomnis………………………………………………………….....
test guide……………………………………………………………………………………
molecular genetics……………………………………………………………………….
microbial genetics……………………………………………………………………….
cytogenetics…………………………………………………………………………….....
autoimmunity……………………………………………………………………………....
serology…………………………………………………………………………………......
cytology…………………………………………………………………………………......
biomnis test list…………………………………………………………………………….
referral request form…………………………………………………………………….
online results……………………………………………………………………………....
table of content
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5
5
5
5
6
9
11
13
15
39
43
44
50
58
60
63
110
111

5
about
about us
biolab is a medical diagnostic laboratory that offers a full range of laboratory services in jordan. recognized
for our innovation, quality and customer focus.
our experience and professionalism
biolab’s competitive edge is quality and convenience through performance and professionalism. here at
biolab we seek excellence in all we do. from high medical expertise to our internal quality assurance, as well
as our effective delivery of health care we set a high bar and without compromise.
our people
biolab’s medical directors and technologists, who are nationally and internationally recognized scientists,
make significant contributions in research and development. they support the medical community by
providing consultation in all aspects of laboratory medicine, including: diagnostic problem solving and
clinical interpretation of test results in molecular diagnostics, cytogenetics, immunology, histopathology and
cytology.
our services
biolab is a pioneer in applying advances in medicine and science to laboratory testing, making it uniquely
positioned to serve physicians and their patients.
we provide a wide range of medical diagnostic services including:
comprehensive diagnostic testing menus in:
• allergy
• antenatal diagnostics
• autoimmunity
• cytogenetics
• endocrinology
• enzymology
• flow cytometry
• gene sequencing
• hematology
• histopathology
custom designed test profiles for doctors, hospitals and corporations
mobile client services (house calls)
pre-employment drug testing
laboratory physician consulting services
employment related and occupational health testing
• human genetics
• immunochemistry
• infectious serology
• microbiology
• molecular genetics
• oncology
• parasitology
• specialized biochemistry
• transfusion medicine
• virology
6
our technologies
biolab is equipped with state-of-the-art equipments and instruments and according to the most recent advancements
in the laboratory industry.
becton dickinson facscalibur
the bd facscalibur™ flow cytometer is a versatile tool with enormous potential for the study of cells and particles.
no other laboratory instrument provides multiparametric analysis at the single cell level, and the flow
cytometer or application-variants of the flow cytometer will become more valuable as medical diagnosis and
therapy changes. a flow cytometer can discriminate cells at speeds up to 70,000cells/second. in addition to
a high speed processing, this instrument offers high fluorescence sensitivity and minimal sample contamination.
the bd facscalibur system can perform a wide range of complex tasks such as immunophenotyping,
which is critical to the initial diagnosis and classification of the acute leukaemias, chronic lymphoproliferative
diseases, and malignant lymphomas. in addition, immunophenotyping provides prognostic information not
available by other techniques, hence provides a sensitive means to monitor the progress of patients after
chemotherapy or bone marrow transplantation, and often permits the detection of minimal residual disease.
all these tasks are performed at biolab in addition to bone marrow transplantation and stem cell analysis,
hiv infection (cd4/cd8) and many applications in research. this technique is used not only for complex tests
performed in clinical laboratories, but also for life science and clinical research applications.
cobas taqman 48
the cobas taqman 48 analyzer is a real-time pcr analyzer that provides unmatched
accuracy, flexibility, maximum efficiency, a superior dynamic range
and contamination risk elimination. this method is mainly utilized for the monitoring
and quantification of target copy numbers of viral load such as hepatitis
b and c viruses. cobas taqman 48 is one of the few worldwide fda approved
instruments.
corbett rotor-gene 6000
real-time polymerase chain reaction (pcr) is the ability to monitor the
progress of the pcr as it occurs. it enables the detection of very small amounts
of specific nucleic acid sequences during the early phases of the reaction
and on a real-time basis. data analysis, including standard curve generation
and copy number calculation, is performed automatically. the rotor-gene is
an innovative real-time cycler that enables high-precision real-time pcr. this
instrument is usually utilized for the detection of infectious diseases.
gene sequencer abi prism – 310 genetic analyzer
dna sequencing by capillary electrophoresis is the ideal alternative to gelbased
dna analysis for any research, clinical or forensic lab. the abi prism®
310 genetic analyzer is an automated single-capillary genetic analyzer designed
for a wide range of sequencing and fragment analysis applications.
it performs comparative sequencing, linkage analysis, snp detection, discovery
and validation, mutation detection, and many other applications.
it allows rapid diagnosis of different diseases. it enables to automate applications
from de novo sequencing to snp validation and linkage mapping.
examples of such applications are amnio pcr for aneuploidy screening
of chromosomes 13, 18, 21, x and y, and duchenne and becker muscular
dystrophy.
7
elecsys (cobas e 411)
it is a superior automated hormonal immunology analyzer,
designed to reduce complexity by consolidating clinical
chemistry and immunochemistry testing proving real efficiency.
this analyzer performs 86 extensive tests in one hour while
handling sample dilution and clot detection if occurred. it is
known for its exclusive electr ochemiluminescence (ecl)
technology, which delivers broad dynamic measuring ranges,
high analytical sensitivity and virtually eliminates repeats and
reruns.
sysmex xt-2000i
designed to be reliable and efficient, the sysmex xt2000i is an
automated hematology system that utilizes the power of fluorescent
flow cytometry and hydrodynamic focusing technologies.
using a unique, state-of-the-art, diode laser bench, sysmex
fluorescent flow cytometry provides the sensitivity needed
for measuring and differentiating cell types in whole blood and
body fluid samples with uncompromised precision and accuracy.
fluorescent technology and hydrodynamic focusing enable
the analyzers to consistently classify normal wbc, rbc,
and plt populations from abnormal populations, thereby decreasing
the number of manual interventions.
applied biosystems 9800 fast thermal cycler
pcr (polymerase chain reaction) is a technique that is central
to molecular biology research and diagnostics. the applied
biosystems 9800 fast thermal cycler (pcr) enables unmatched
speed and performance, and provides reproducible, specific
and sensitive pcr results. this is usually utilized in gene mutation
amplification.
cobas (integra 400 plus)
cobas (integra 400 plus) is a sensitive and delicate automated
clinical chemistry analyzer that performs more than 140 applications
for all types of sample matrices with one of 4 different
measuring technologies – absorbance photometry, turbidimetry,
fluorescence polarization and ion selective potentiometry. it represents
ultimate combination of convenience and security for
accurate and high quality results. in addition, it can also analyze
about 400 tests onboard in only one hour delivering the maximum
versatility and ease of operation.
8
sysmex (kx – 21n)
sysmex (kx-21n) is a break-through automated hematology
analyzer. it is known for its simplicity and flexibility in
handling high workloads of specimens up to 60samples/
hour. it is an innovative technology that performs rapid
and accurate analysis of 17 parameters compact and
fully integrated ideal for clinical diagnostic hematology
results and unique in its on-board storage capacity for
numerical results as well as graphical data.
bio-rad d-10
the bio-rad d-10 comprehensive, fully automated hemoglobin
testing system is a bench top high-performance
liquid chromatography (hplc) system dedicated to the
quantification of hba1c, hba2 and hbf in whole blood.
combining diabetes and ?-thalassemia testing on a single
platform, the system offers simple, efficient operation, developed
for flexibility and reliability. whole blood primary
tube sampling eliminates off-line sample preparation.
9
test procedure
all tests are performed according to written procedures, and updatingd in line with technical developments.
the preparation, set up and analytical and pathological validation of tests are subject to written procedures.
the internal quality control for each test is subject to a detailed description in terms of control samples, testing
conditions, acceptability guidelines and the anomaly procedure. biolab takes part in various external control
programs so as to validate the methods used and detect any anomalies.
the request form
clear and legible completion of the request form is an essential requirement for acceptance of samples. the
following details are required.
patient details
• full name
• hospital/lab/clinic reference number
• date of birth
• sex
referral details
• full name of referring clinician (no initials please)
• contact telephone number of referring clinician
• tests required
sample details
• type of sample
• date and time of sample obtained and collected
clinical details
• appropriate application of tests is entirely dependent upon the information we receive from you.
please provide us with all relevant clinical details, family history and results of any previous genetic testing
that may have been carried out (with name of laboratory and reference numbers if possible).
• reasons for referral.
• it is strongly recommended that when taking a blood sample, the patient is asked to list the medications
currently used (if applicable). this information is crucial, as some medications may inhibit or interfere
with some of the tests performed.
sample handling
• put the sample in the appropriate container tube (refer to next section).
• label with patient name and patient reference number.
• place in a sealed, leak-proof sample bag.
• place the sample bag in a rigid container (isothermal shipping box).
• the request form should be put inside the box.
• transport to the laboratory as soon as possible, preferably on the day of sampling.
• frozen samples must be transferred at -20°c with the appropriate amount of dry ice (not less than 4kgs).
• refrigerated samples must be transferred at 4°c (placed on top of cold cells).
• ambient samples must be transferred at room temperature (do not freeze or expose to heat).
prior arrangement is required before and during holidays and long weekends, as delay may influence cellular
viability.
practical information
10
urgent samples
• prenatal and neonatal samples are always treated as urgent by the laboratory. for other urgent samples,
please state ‘urgent’ clearly on the request form.
high risk samples
• samples from high-risk patients (e.g. carriers of hiv, hepatitis b, and hepatitis c) must be labeled with an
appropriate hazard warning sticker. the nature of the risk must be clearly stated on the request form.
• high risk samples requiring containment level 3 facilities, e.g. known cases of sars, nvcjd etc. cannot be
processed.
sample rejection
samples arriving in a totally unsuitable condition are unlikely to produce satisfactory results, therefore are
not processed, and a repeat sample will be requested, e.g.:
• sample in wrong tube or wrong temperature
• sample delayed in transit for more than the maximum transit stated
• sample clotted
• non-viable sample (lyzed, infected, exposed to a fixative, dried, exposed to high temperature)
• broken sample tube
• spilled samples
• sample quantity not sufficient for testing (see table 2)
• inadequate labeling
- the referral request form and sample must be labeled with the name and details of the patient to be
tested (not those of another family member such as the wife or mother).
- inadequate labeling of a sample (e.g. discrepancy between name on sample and name on referral
request form or no name on sample or no name on r equest form) may result in a sample not being
processed.
- a minimum of two identifiers should be present on the sample tube (e.g. patient’s name, your lab/clinic/
hospital reference number)
patient consent form
informed patient consent is required for all genetic tests from all patients. the laboratory assumes that provision
of clinical sample, and a signed referral form, implies that consent form provided has been signed.
results
• results are validated and, thus released online (www.biolab.jo) as soon as the test is completed and the
results have been authorized by qualified staff.
• telephone reporting of results is discouraged due to the risk of error in verbal transmission.
• requests for results to be faxed or e-mailed may be made by telephoning, faxing or emailing the referral
department (refer to page 3).
11
director: miza hijazi
location: fifth circle
13 suleiman hadidi st. – jume’an building
tel: 5920036, fax: 5939430
amman, jordan
director: jamal al khalil
location: near khalidi hospital
52 ibn khaldoun st. – quraini medical building
tel: 4641155, fax: 4640900
amman, jordan
our laboratories
2
1
center
director: dr. ghada mulla hweish
location: fifth circle
13 khalil maz’al st. – hanania medical center
tel: 5924385, fax: 5934386
amman, jordan
director: dr. amid abdelnour
location: fifth circle
15 suleiman hadidi st – abdoun clinics
tel: 5937376, fax 5926780
amman, jordan

13
biolab has partnered with biomnis, the leading specialist in medical testing in france, which bases itself on
a concept of laboratory analysis that is both multidisciplinary and specialized. this partnership allows biolab
to provide an extensive high-quality test menu of highly complex and unique medical tests to patients and
physicians.
aiming at providing physicians with the most reliable tests for the diagnosis and management of health problems,
biolab will continue to be a pioneer in applying advances in medicine and science to laboratory testing.
biomnis represents first and foremost, state-of-the-art expertise for first-line laboratories with the interpretation
of results to improve prevention, screening, diagnosis and therapeutic efficacy monitoring.
please refer to page 63 for biomnis test list.
partners with biomnis
view the results online
www.biolab.jo
15
test guide
referral price list
test name sample
type
transport
conditions
tat notes
17-beta estradiol - e2 1 ml serum rt daily state day of
menstrual cycle
17-hydroxy progesterone 1 ml serum rt 3 d
1st trimester prenatal interpretive screening 2 ml serum rt daily attach physician s
prescription
5-hydroxy indole acetic acid (5-hiaa) 30 ml of 24 hr
urine
rt 3 d call lab
a
acetaminophen (paracetamol) 1 ml serum rt daily
acetylcholine receptor (achr) antibodies, quantitative 1 ml serum rt 7 d
acetylcholine receptor (achr) antibodies, screen 1 ml serum rt daily
acid phosphatase, prostatic 2 ml serum 2-8oc daily
acid phosphatase, total 2 ml serum 2-8oc daily
activated protein c resistance (factor v leiden) g1691a mutation,
pcr
3 ml edta
whole blood
rt 4 d
activated protein c resistance (factor v leiden), functional 2 ml citrated
plasma
frz 4 d fresh sample,
send frozen
adenovirus and rotavirus stool rt daily fresh sample
adenovirus antibodies, igg 1 ml serum rt daily
adenovirus antibodies, igm 1 ml serum rt daily
adh (ant diuretic hormone vasopressin) 2 ml edta
plasma
frz 1 w fasting, fresh,
send frozen
adrenal antibodies 1 ml serum rt daily
adrenaline (epinephrine) 24 hr urine 2-8oc 4 d
adrenocorticotropic hormone (acth) 2 ml edta
plasma
frz daily fresh sample,
send frozen
alanine aminotransferase (alt/gpt) 1 ml serum rt daily
albumin 1 ml serum rt daily
aldolase 1 ml serum 2-8oc daily
aldosterone 2 ml serum frz 1 w fresh, frozen, upright
or supine?
16
referral price list
test name sample
type
transport
conditions
tat notes
alkaline phosphatase 1 ml serum rt daily
alkaline phosphatase isoenzymes 1 ml serum rt 1 w fasting
allergen specific ige, food panel (35 allergens) 1 ml serum rt daily
allergen specific ige, inhalants panel (28 allergens) 1 ml serum rt daily
allergen specific ige, pediatric panel (27 allergens) 1 ml serum rt daily
alpha-1-antitrypsin (a1a) 1 ml serum rt daily
alpha-fetoprotein (pregnant woman) 1 ml serum rt daily gestational age
alpha-fetoprotein (tumour marker) 1 ml serum rt daily
alpha-fetoprotein, amniotic fluid 3 ml amniotic
fluid
rt daily gestational age
alpha-globin gene (a-thalassemia) mutations, pcr (21 mutations) amniotic fluid rt 7 d
alpha-globin gene (a-thalassemia) mutations, pcr, (21 mutations) 2 ml edta
whole blood
rt 7 d
alpha-globin gene (a-thalassemia) mutations, pcr, (21 mutations) chorionic villus
sample
rt 7 d
aluminum 2 ml serum rt call lab
amikacin 1 ml serum rt daily draw blood predose
amino acids, quantitative 2 ml edta
plasma
frz 3 d deliver immediately
amino acids, quantitative 30 ml of urine frz 3 d call lab
ammonia, plasma 2 ml edta
whole blood
2-8oc daily vacutainer, keep
under vaccum,
under ice
amniopcr, chromosome x, y, 13, 18, and 21 abnormalities,qf-pcr 3 ml amniotic
fluid
rt 2-3 d
amphiphysin antibodies, serum 1 ml serum rt daily
amylase 5 ml 24 hr urine
or spot urine
rt daily
amylase 1 ml body fluid rt daily
amylase 1 ml serum rt daily
ana 1 ml serum rt daily
anca 1 ml serum rt daily
androstenedione 1 ml serum frz daily send frozen
angiotensin converting enzyme (ace) 1 ml serum rt daily
17
referral price list
test name sample
type
transport
conditions
tat notes
anti ccp 1 ml serum rt daily
anti gad 1 ml serum rt daily
anti myelin antibodies, serum 1 ml serum rt daily
anti thrombin iii 2 ml citrated
plasma
frz daily send frozen
anti-musk antibodies, serum 2 ml serum rt 2 w
apolipoprotein a1 1 ml serum 2-8oc daily fasting
apolipoprotein b 1 ml serum 2-8oc daily fasting
asca, iga 1 ml serum rt 3 d
asca, igg 1 ml serum rt 3 d
aso 1 ml serum rt daily
aspartate aminotransferase (ast/got) 1 ml serum rt daily
autoimmune liver antigen profile (sla, m2, lkm, lc1) 1 ml serum rt daily
b
bence jones protein 20 ml of 24 hr
urine or spot
urine
rt daily
benzodiazepines, quantitative 5 ml of urine rt 2 d
beta-2-glycoprotein 1 antibodies iga, serum 2 ml serum rt 3 d
beta-2-glycoprotein 1 antibodies igg, serum 2 ml serum rt 3 d
beta-2-glycoprotein 1 antibodies igm, serum 2 ml serum rt 3 d
beta-2-microglobulin (b2-m), serum 1 ml serum frz 3 d send frozen
beta-carotene (vitamin a) 2 ml serum rt 3 d protect from light
beta-globin gene, ?- thalassemia (22 mutations), pcr 7-10ml
amniotic fluid
rt 17 d
beta-globin gene, ?- thalassemia (22 mutations), pcr 3 ml edta
whole blood
rt 4 d
beta-globin gene, ?- thalassemia (22 mutations), pcr chorionic villus
sample
rt 17 d
beta-human chorionic gonadotropin (?-hcg) 1 ml serum rt daily state day of last
menstrual cycle
beta-human chorionic gonadotropin (?-hcg), tumor marker 1 ml serum rt daily
18
referral price list
test name sample
type
transport
conditions
tat notes
beta-lactoglobulin (cow s milk and soya) antibodies, igg 3 ml serum rt daily
bilirubin 10 ml urine
(spot urine)
rt daily protect from light
bilirubin, direct, serum 1 ml serum rt daily protect from light
bilirubin, total, serum 1 ml serum rt daily protect from light
billirubin spectral curve (liley zone) 10 ml amniotic
fluid
rt daily protect from light
bladder tumor antigen (nmp22) 10 ml urine rt daily
blood culture, automated whole blood
in specialized
bottle
rt 7 d
blood film 1 ml edta
whole blood
rt daily
blood group and rh typing 1 ml edta
whole blood
rt daily
blood sugar 1 ml serum rt daily
blood urea nitrogen (bun) 1 ml serum rt daily
body fluid analysis, cell count and chemical 5 ml body fluid rt daily
borrelia burgdorferi (lyme disease) antibodies, igg 1 ml serum rt daily
borrelia burgdorferi (lyme disease) antibodies, igm 1 ml serum rt daily
brucella antibodies, igg 1 ml serum rt 3 d
brucella antibodies, igm 1 ml serum rt 3 d
brucella antibodies, total, titer 1 ml serum rt 2 d
b-type natriuretic peptide, serum (bnp) 2 ml edta
plasma
rt daily send frozen
c
c1 esterase inhibitor (c1s), serum 1 ml serum frz 3 d send frozen
c3, 3rd component of complement, serum 1 ml serum rt daily
c4, 4th component of complement, serum 1 ml serum rt daily
ca 125, serum 1 ml serum rt daily
ca 15-3, serum 1 ml serum rt daily
ca 19-9, serum 1 ml serum rt daily
ca 72-4, serum 1 ml serum rt daily
19
referral price list
test name sample type transport
conditions
tat notes
cadmium, blood 5 ml heparin
whole blood
rt 3 d do not separate
calcitonin, serum 1 ml serum frz daily fresh, frozen
calcium 5 ml 24 hour
urine or spot
urine
rt daily
calcium, ionised 1 ml serum rt daily vacutainer, keep
under vacuum
calcium, serum 1 ml serum rt daily
carbamazepine (tegretol), serum 1 ml serum rt daily draw blood predose
cardiolipin antibodies, igg, serum 1 ml serum rt daily
cardiolipin antibodies, igm, serum 1 ml serum rt daily
cardiovascular disease associated risk, 12 mutation profile, pcr 3 ml edta whole
blood
rt 4 d
carnitine, hplc 1 ml serum, seminal
fluid, edta
plasma
rt 3 d send frozen
catecholamines fractionation (adrenaline, noradrenaline, dopamine)
24 hr urine rt 4 d
catecholamines, fractionation (adrenaline, noradrenaline, dopamine)
edta plasma rt 4 d
catecholamines, free 24 hr urine 2-8oc 4 d
catecholamines, total 24 hr urine 2-8oc 4 d
cea, serum 1 ml serum rt daily
centromere antibodies, serum 1 ml serum rt daily
cerebrospinal fluid ab s, igg index 3 ml csf and 1
ml serum
rt 4 d
cerebrospinal fluid analysis 3 ml csf and 1
ml serum
rt daily
ceruloplasmin, serum 1 ml serum rt daily
chlamydia trachomatis antibodies, iga, serum 1 ml serum rt daily
chlamydia trachomatis antibodies, igg, serum 1 ml serum rt daily
chlamydia trachomatis antibodies, igm, serum 1 ml serum rt daily
chlamydia trachomatis dna,rt- pcr qualitative endocervical
urethral, urine
sample
rt 4 d
chloride 5 ml of 24hr urine
or spot urine
rt daily
20
referral price list
test name sample type transport
conditions
tat notes
chloride 1 ml serum rt daily
chloride 5 ml body fluid rt daily
cholesterol, total 1 ml serum rt daily
cholinesterase, serum 3 ml serum rt daily
chromosomal breakage (ataxia telangiectasia,
fanconi’s anemia)
2-4 ml heparin
whole blood
rt 1 w deliver to the lab
within 48 hrs
chromosomal karyotyping, amniotic fluid 15-20 ml amniotic
fluid
rt 2 w sterile sample,
plastic
chromosomal karyotyping, bone marrow 2-5 ml bone marrow
aspirate
rt 5 days sterile sample,
plastic
chromosomal karyotyping, chorionic villus sampling 2-25 mg in universal
container
rt 2 w sterile sample,
plastic
chromosomal karyotyping, fetal blood/ cord 0.5-1 ml heparin rt 1 w sterile sample,
plastic
chromosomal karyotyping, fragile x syndrome 2-4 ml heparin
whole blood
rt 1 w sterile sample,
plastic
chromosomal karyotyping, peripheral blood 2-4 ml heparin
whole blood
rt 1 w sterile sample,
plastic
chromosomal karyotyping, products of conception abortus rt 2 w sterile sample,
plastic
cll panel / gli: (12q13), atm: (11q22), p53: (17p13), dleu: 13q14 2 ml heparin
whole blood
rt 3 d plastic, sterile
clostridium difficile toxin a, stool stool or proctoscopic
specimen
rt daily
complement hemolytic activity (ch50), serum 2 ml serum frz 1 w send frozen
complete blood count (cbc) with blood film 2 ml whole
blood edta
rt daily
coomb`s test, direct 2 ml whole
blood edta
rt daily
coomb`s test, indirect 1 ml serum rt daily
copper, 24 hrs, urine 30 ml of 24 hrs
urine
rt 3 d call lab
copper, serum 2 ml serum rt daily
cortisol, free, 24 hrs, urine 30 ml of 24hr
urine
rt daily
cortisol, total, serum 1 ml serum rt daily
coxiella burnetii (q- fever) antibodies, igg, serum 1 ml serum rt daily
coxiella burnetii (q- fever) antibodies, igm, serum 1 ml serum rt daily
21
referral price list
test name sample type transport
conditions
tat notes
coxsackie virus (a7, 9, 16 & 24) antibodies, igg, serum 2 ml serum rt daily
coxsackie virus (a7, 9, 16 & 24) antibodies, igm, serum 2 ml serum rt daily
coxsackie virus b1-6 antibodies, igg, serum 1 ml serum rt daily
coxsackie virus b1-6 antibodies, igm, serum 1 ml serum rt daily
c-peptide, serum 2 ml serum frz daily fasting, fresh,
send frozen
c-reactive protein, high sensitivity (hs-crp), serum 1 ml serum rt daily
creatine kinase mb fraction (ck-mb), serum 1 ml serum rt daily
creatine phosphokinase (cpk), serum 1 ml serum rt daily
creatinine clearance, serum & urine 1 ml serum and
10 ml 24 hr urine
rt daily
creatinine, 24 hrs, urine 5 ml 24 hr urine
or spot urine
rt daily
creatinine, serum 1 ml serum rt daily
culture (mycobacteria, fungal or special conditions) from corresponding
site
rt call lab
culture identification & antibiotic sensitivity/ ordinary from corresponding
site
rt 3 d
culture, blood (identification & sensitivity) whole blood
in specialized
bottles
rt 7 d
cyclic citrullinated peptide (ccp) antibodies, serum 1 ml serum rt daily
cyclosporine, blood level 2 ml edta whole
blood
rt daily
cystatin c, serum 2 ml serum rt daily
cystic fibrosis (36 mutation), amniotic fluid amniotic fluid rt 17 d
cystic fibrosis (36 mutation), blood 2 ml whole
blood edta
rt 1 w
cystic fibrosis (36 mutation), cvs chorionic villus
sample
rt 17 d
cystine, qualitative, urine 20 ml of 24 hr
urine
rt 2 d
cytology (body fluids) from corresponding
site
rt 2 d
cytology, fna (fine needle aspiration) from corresponding
site
rt 2 d
cytology, pap smear from corresponding
site
rt 2 d
cytomegalovirus (cmv) antibodies, igg, serum 1 ml serum rt daily
cytomegalovirus (cmv) antibodies, igm, serum 1 ml serum rt daily
22
referral price list
test name sample type transport
conditions
tat notes
cytomegalovirus (cmv) dna, qualitative, pcr 2 ml serum, csf rt 4 d
cytomegalovirus (cmv) dna, quantitative 2 ml edta
plasma
rt 4 d
cytotoxic antibodies heparin whole
blood + serum
rt daily serum from
recipient and
whole blood from
donor
d
d-dimer, plasma 3 ml citrated
plasma
frz daily send frozen
dehydroepiandrosterone sulphate (dhea-s), serum 2 ml serum 2-8 oc daily
delta aminolevulinic acid (dala), urine 10 ml 24 hr urine 2-8 oc 3 d protect from light
digoxin, serum 1 ml serum rt daily
dihydrotestosterone, serum 1 ml serum rt 3 d
dna antibodies, double stranded (ds), serum 1 ml serum rt daily
drug screen (10 drugs) 10 ml urine (spot
urine)
rt daily
du test (rh typing) 1 ml edta whole
blood
rt daily
dual screen (maternal) 2 ml serum rt daily
duchenne & becker muscular dystrophy (dmd/bmd), genetic
analysis, amniotic fluid
3 ml amniotic
fluid
rt 30 d sterile sample
duchenne & becker muscular dystrophy (dmd/bmd), genetic
analysis, chorionic villus sampling
cvs sample in
universal container
rt 30 d sterile sample
duchenne & becker muscular dystrophy (dmd/bmd), genetic
analysis, peripheral blood
3 ml edta whole
blood
rt 18-20 d sterile sample
e
echinococcus antibodies, serum 1 ml serum rt 2 d
echovirus antibodies, igg, serum 1 ml serum rt 2 d
echovirus antibodies, igm, serum 1 ml serum rt daily
electrolytes(na, k, cl), serum level 1 ml serum rt daily
endomysial antibodies, iga, serum 1 ml serum rt daily
endomysial antibodies, igg, serum 1 ml serum rt daily
endomysial antibodies, igm, serum 1 ml serum rt daily
23
referral price list
test name sample type transport
conditions
tat notes
entamoeba histolytica antigen, stool stool rt daily
epstein barr virus, viral (ebv) capsid antigen (vca) antibodies, igg,
serum
1 ml serum rt daily
epstein barr virus, viral (ebv) capsid antigen (vca) antibodies, igm,
serum
1 ml serum rt daily
erythrocyte osmotic fragility, blood 5 ml heparin
blood
rt 2 d fresh sample
erythropoietin (epo), serum 1 ml serum rt daily
estriol, free (fe3), serum 1 ml serum rt 3 d
ethanol (alcohol) 2 ml serum, spot
urine
2-8oc daily vacutainer,
keep vacuum,
fresh
extractable nuclear antigens (ena) antibodies, serum 1 ml serum rt daily
f
factor ii assay, plasma 2 ml citrated
plasma
frz call lab
factor ii prothrombin g20210a mutation, pcr, blood 2 ml edta whole
blood
rt 4 d
factor ix assay, plasma 2 ml citrated
plasma
frz 2 d
factor v assay, plasma 2 ml citrated
plasma
frz call lab
factor v g1691a (leiden) gene mutation (for cvd and recurrent
abortion)
2 ml edta whole
blood
rt 4 d
factor vii assay, plasma 2 ml citrated
plasma
frz call lab
factor viii, plasma 2 ml citrated
plasma
frz 2 d
factor x assay, plasma 2 ml citrated
plasma
frz daily
factor xi assay, plasma 2 ml citrated
plasma
frz 10 d
factor xii assay, plasma 2 ml citrated
plasma
frz 10 d
factor xiii assay, plasma 2 ml citrated
plasma
frz 10 d
factor xiii mutation, pcr 3 ml edta rt 4 d
familial mediterranean fever (fmf) mutations 3 ml edta whole
blood
rt 4 d
fasting blood sugar (glucose), serum 1 ml serum rt daily
ferritin, serum 1 ml serum rt daily
fibrinogen degradation product (fdp), plasma 2 ml citrated
plasma
frz daily send frozen, call
lab
fibrinogen, plasma 2 ml citrated
plasma
frz daily send frozen
24
referral price list
test name sample type transport
conditions
tat notes
fine needle aspiration (fna) from corresponding
site
rt 2 d
first trimester screen 2 ml serum rt 2 d
fish ( rapid sexing x and y) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (13) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (13,18) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (13,18,21) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (13,18,21,x,y) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (18) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (21) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (digeorge) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (miller dieker) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (prader- willi) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
fish (x,y,21) amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d sterile sample,
plastic
folate, serum 1 ml serum rt daily protect from light
follicle stimulating hormone (fsh), serum 1 ml serum rt daily state day of
menstrual cycle
food intolerance test by imupro100 2 ml serum rt 7-10 d
food intolerance test by imupro300 2 ml serum rt 7-10 d
free beta-human chorionic gonadotropin (b-hcg), serum 1 ml serum rt daily
fructose, semen 1 ml seminal
fluid
rt daily
g
g6pd 1 ml edta whole
blood
rt daily
25
referral price list
test name sample type transport
conditions
tat notes
galactose 1-phosphate uridyltransferase (galt) 4 ml heparin
blood
rt 3 d do not separate
gamma-glutamyl transferase (g-gt), serum 1 ml serum rt daily
ganglioside antibodies profile (gd1a, gd1b, gt1b, gq1b, gm1, 2,
and 3) igg serum
3 ml serum rt daily
gastrin, serum 1 ml serum frz daily fasting, send
frozen
gentamicin, serum 1 ml serum rt daily trough or peak
level
giardia lamblia antigen, stool stool rt daily
gliadin antibodies, iga, serum 1 ml serum rt daily
gliadin antibodies, igg, serum 1 ml serum rt daily
glomerular basement membrane (gbm) antibodies, serum 1 ml serum rt daily
glucose 6-phosphate dehydrogenase (g6pd), erythrocytes 1 ml edta whole
blood
rt daily
glucose tolerance test/ sample 1 ml serum each
time point
rt daily
glucose, serum 1 ml serum rt daily
glutamic acid decarboxylase (gad) antibodies, serum 1 ml serum rt daily
glycosylated hemoglobin (hba1c), blood 1 ml edta whole
blood
rt daily
got (ast) 1 ml serum rt daily
gpt (alt) 1 ml serum rt daily
gram stain smear or swab
from the site
rt daily
growth hormone, serum 1 ml serum frz daily send frozen
h
ham`s test, blood 2 ml edta whole
blood
rt 2 d
haptoglobin, serum 1 ml serum rt daily
hba1c 1 ml edta whole
blood
rt daily
hdl 1 ml serum rt daily
26
referral price list
test name sample type transport
conditions
tat notes
heinz inclusion bodies, blood 1 ml edta whole
blood
rt 2 d
helicobacter pylori antibodies, iga, serum 1 ml serum rt daily
helicobacter pylori antibodies, igg, serum 1 ml serum rt daily
helicobacter pylori antigen, stool stool frz ,or fresh daily fresh, or frozen
hemoglobin electrophoresis (minicap) 2 ml edta whole
blood
rt daily
hemoglobin, total 1 ml edta whole
blood
rt daily
hemosiderin, spot urine spot urine rt daily fresh sample
heparin/ anti platelets factor 4 2 ml serum frz daily
hepatitis a virus antibodies, igm, serum 1 ml serum rt daily
hepatitis a virus antibodies, total, serum 1 ml serum rt daily
hepatitis b virus (hbv) dna quantitative, rt-pcr
(taqman)
1 ml serum frz 4 d send frozen, (sat,
tue, run starts at
10 am)
hepatitis bc antibodies (hbcab), total, serum 1 ml serum rt daily
hepatitis bc igm antibodies (hbcab-igm), serum 1 ml serum rt daily
hepatitis be antibodies (hbeab), serum 1 ml serum rt daily
hepatitis be antigen (hbeag), serum 1 ml serum rt daily
hepatitis bs antibodies (hbsab), serum 1 ml serum rt daily
hepatitis bs antigen (hbsag), serum 1 ml serum rt daily
hepatitis c virus (hcv) genotyping, rt-pcr, serum 1 ml serum frz 1 w
hepatitis c virus (hcv) rna, quantitative, rt-pcr (taqman) 1 ml serum frz 4 d send frozen, (sun,
wed, run starts at
10 am)
hepatitis c virus (hcv) total antibodies, serum 1 ml serum rt daily
hepatitis delta virus (hdv) antibodies,total, serum 1 ml serum rt 1 w
hepatitis delta virus (hdv) antibodies, igm, serum 1 ml serum rt 3 d
hepatitis e virus (hev) antibodies, igm, serum 1 ml serum rt 3 d
hereditary hemochromatosis mutation (c282y, h63d, & s65c), pcr 3 ml edta whole
blood
rt 4 d
herpes simplex virus i & ii antibodies, igg, serum 1 ml serum rt daily
herpes simplex virus i & ii antibodies, igm, serum 1 ml serum rt daily
27
referral price list
test name sample type transport
conditions
tat notes
herpes simplex virus i antibodies, igg, serum 1 ml serum rt daily
herpes simplex virus i antibodies, igm, serum 1 ml serum rt daily
herpes simplex virus ii antibodies, igg, serum 1 ml serum rt daily
herpes simplex virus ii antibodies, igm, serum 1 ml serum rt daily
herpes simplex virus type i & ii dna (hsv i & ii), pcr genital swab
and/or body
fluids
rt 4 d
high density lipoprotein (hdl) cholesterol, serum 1 ml serum rt daily
hiv 1 & 2 antibodies/ antigen assay (combo), serum 1 ml serum rt daily
hiv rna , quantitative (pcr) 2 ml edta
plasma
rt 4 d
hla ab by pcr 4 ml edta whole
blood
rt 4 d
hla ab- dr by pcr 4 ml edta whole
blood
rt 4 d
hla abc by pcr 4 ml edta whole
blood
rt 4 d
hla abc- dr by pcr 4 ml edta whole
blood
rt 4 d
hla dr by pcr 4 ml edta whole
blood
rt 4 d
hla-b27, blood, pcr 3 ml edta whole
blood
rt 4 d
hla-b5 (b51, b52) blood, pcr 3 ml edta whole
blood
rt 4 d
homocysteine, serum 1 ml serum rt daily fasting
htlv i/ii, screening serology, serum 2 ml serum rt 3 d
human leukocyte antigens typing, hla- a, b, c by pcr 5 ml edta whole
blood
rt 4 d
human leukocyte antigens typing, hla ab by pcr 5 ml edta whole
blood
rt 4 d
human leukocyte antigens typing, hla abc-dr by pcr 5 ml edta whole
blood
rt 4 d
human leukocyte antigens typing, hla ab-dr by pcr 5 ml edta whole
blood
rt 4 d
human leukocyte antigens typing, hla-dr by pcr 5 ml edta whole
blood
rt 4 d
human oncogenes, breast cancer genes (brca1, brca2), gene
analysis, pcr
5 ml edta whole
blood
rt 30 d
human papillomavirus (hpv) genotyping, pcr vaginal biopsy,
body fluid or
smear
rt 7 d
i
igg subclasses 1 ml serum rt 1 w
28
referral price list
test name sample type transport
conditions
tat notes
immunofixation 30 ml of 24 hrs
urine
rt 3 d
immunofixation, serum 1 ml serum rt 3 d
immunoglobulin a (iga), serum 1 ml serum rt daily
immunoglobulin d (igd), serum 1 ml serum rt 3 d
immunoglobulin e (ige), serum 1 ml serum rt daily
immunoglobulin g (igg), serum 1 ml serum rt daily
immunoglobulin m (igm), serum 1 ml serum rt daily
infectious mononucleosis, rapid test, serum 1 ml serum rt daily
influenza a & b rapid test nasal swab rt daily transport in normal
saline
influenza virus a, rna by rt-pcr nasal swab rt daily transport in normal
saline
influenza virus strain a antibodies, igg, serum 1 ml serum rt daily
influenza virus strain a antibodies, igm, serum 1 ml serum rt daily
influenza virus strain b antibodies, igg, serum 1 ml serum rt daily
influenza virus strain b antibodies, igm, serum 1 ml serum rt daily
inhibin a (prenatal screen) maternal serum 1 ml serum frz 3 d send frozen
inhibin a, serum 1 ml serum frz 3 d send frozen
inhibin b, serum 1 ml serum frz 4 d send frozen
insulin antibodies, serum 1 ml serum rt 3 d
insulin tolerance test / sample 1 ml serum at
each time point
frz daily fasting, fresh
insulin, serum 1 ml serum frz daily fasting, fresh
insulin-like growth factor 1, serum 1 ml serum rt daily fasting
insulin-like growth factor binding protein-3, serum 1 ml serum rt 3 d fasting
intrinsic factor blocking antibodies, serum 1 ml serum rt 2 d
iron, serum 1 ml serum rt daily
j
jak2 gene - val617phe (v617f) mutation - whole blood 2 ml edta whole
blood
rt 3 d
29
referral price list
test name sample type transport
conditions
tat notes
l
lactate dehydrogenase (ldh) isoenzymes, serum 1 ml serum rt 1 w
lactate dehydrogenase (ldh), serum 1 ml serum rt daily
lactose tolerance test 1 ml serum at
each time point
rt daily
lamotrigine (lamictal), serum level 1 ml serum rt 3 d pre-dose
langerhans cell antibodies 1 ml serum rt daily
lead, 24 hrs urine 24 hr urine rt call lab
lead, blood 2 ml edta whole
blood
rt 2 d
legionella pneumophilia antibodies, igg, serum 1 ml serum rt 3 d
legionella pneumophilia antibodies, igm, serum 1 ml serum rt 3 d
leishmania antibodies, igg, serum 1 ml serum rt 3 d
leishmania antibodies, igm, serum 1 ml serum rt 3 d
leishmania smear, exudate exudate from
corresponding
site
rt 2 d
leukocyte alkaline phosphatase (lap) score 4 ml heparin
whole blood
rt call lab call lab, fresh
liley`s zone for amniotic fluid 10 ml amniotic
fluid
rt daily
lipase, serum 1 ml serum rt daily fasting
lipoprotein (lp) a, serum 1 ml serum rt daily
lipoprotein electrophoresis, serum 1 ml serum rt 4 d
listeria antibodies(m.1/2a, mono.4b) /igg 1 ml serum rt 3 d
listeria antibodies(m.1/2a, mono.4b) /igm 1 ml serum rt 3 d
lithium, serum 1 ml serum rt daily
low density lipoprotein (ldl) cholesterol, serum 1 ml serum rt daily
low molecular weight, heparin 2 ml citrated
plasma
call lab daily
lupus anticoagulant (lac), plasma 3 ml citrate
plasma
frz daily fresh, send frozen
luteinizing hormone (lh), serum 1 ml serum rt daily state day of
menstrual cycle
lymphocytotoxicity heparin whole
blood(donor),
serum(patient)
rt daily
30
referral price list
test name sample type transport
conditions
tat notes
m
magnesium 24 hr urine rt daily
magnesium, serum 1 ml serum rt daily
malaria antibodies, serum 1 ml serum rt daily
malaria smear, blood 2 ml edta whole
blood
rt 2 d
manganese, serum 2 ml heparinized
whole blood
rt call lab
measles (rubeola) virus antibodies, igg, serum 1 ml serum rt daily
measles (rubeola) virus antibodies, igm, serum 1 ml serum rt daily
metanephrines, total 20 ml of 24 hr
urine
2-8oc 3 d call lab
methotrexate, serum 1 ml serum rt daily state time of last
dose
microalbuminuria 10 ml of 12 hr
or 24 hr or spot
urine
rt daily
microdeletion syndromes, genetic analysis, pcr 3 ml edta whole
blood, amniotic
fluid
rt 21 d
mitochondrial antibodies (ama), serum 1 ml serum rt daily
monospot 1 ml serum rt daily
mthfr gene mutation (a1298c), pcr, blood 3 ml edta whole
blood
rt 4 d
mthfr gene mutation (c677t), pcr, blood 3 ml edta whole
blood
rt 4 d
mucopolysaccharides acid screen, spot urine 10 ml urine (spot
urine)
2-8oc daily fresh sample
mullerian hormone antibodies, serum 2 ml serum rt 2 d
multi drug screen 10 ml urine (spot
urine)
rt daily
mumps virus antibodies, igg, serum 1 ml serum rt daily
mumps virus antibodies, igm, serum 1 ml serum rt daily
mycobacterium tuberculosis (tb) quantiferon-gold 1 ml whole
blood in special
tube
rt 2 w
mycobacterium tuberculosis, dna, rt- pcr body fluids or
urine
rt 4 d
mycoplasma pneumonia, pcr throat swab
or respiratory
specimen
rt 7 d
mycoplasma pneumoniae antibodies, igg, serum 1 ml serum rt daily
31
referral price list
test name sample type transport
conditions
tat notes
mycoplasma pneumoniae antibodies, igm, serum 1 ml serum rt daily
myelin antibodies 1 ml serum rt daily
myelin-associated glycoprotein antibodies (mag), serum 2 ml serum rt daily
myeloperoxidase (mpo) antibodies, serum 1 ml serum rt daily
myoglobin quantitative, serum 1 ml serum or
spot urine
2-8oc daily
n
nasal smear for eosinophils nasal fluid rt daily
neisseria gonorrhoea dna, pcr urine or urethral,
vaginal discharge
rt 4 d
neonatal screening profile (1): tsh, g6pd,17-ohp, irt, galactose,
haemoglobinopathies, amino acids, fatty acids, organic acids(45
disorders)
4 blood dropings on
card
rt 1 w
neonatal screening profile (2): amino acids, fatty acids, organic
acids(39 disorders)
4 blood dropings on
card
rt 1 w
neuronal nuclear antigens antibodies (anna), igg serum 1 ml serum rt daily
neuron-specific enolase (nse), serum 1 ml serum rt daily
neutrophil cytoplasmic antibodies (anca), serum 1 ml serum rt daily
nitroblue tetrazolium (nbt), neutrophil function test 3 ml edta whole
blood
rt 7 d sample must be
fresh
nuclear antibodies (ana), serum 1 ml serum rt daily
o
oligoclonal banding, serum & csf 3 ml csf and 1
ml serum
rt 4 d
organic acids (quantitative) spot urine, 24 hr
urine
rt 3 d
osmolality, serum 2 ml serum rt daily
osmolality, urine 5 ml urine rt daily
osmotic fragility test 5 ml heparin
whole blood
rt 2 d sample must be
fresh
osteocalcin heparinized
plasma
rt daily under ice
ovarian antibodies, serum 1 ml serum rt daily
oxalate, 24 hrs urine 5 ml 24 hr urine
or spot urine
2-8oc daily
p
pancreatic langerhans islet cell antibodies, serum 1 ml serum rt daily
32
referral price list
test name sample type transport
conditions
tat notes
panel reactive antibodies 3 ml serum rt call lab
pap smear from corresponding
site
rt 2 d
parathyroid hormone (pth), plasma 1 ml edta
plasma
rt daily
parietal cell antibodies (apca), serum 1 ml serum rt daily
partial thromboplastin time (ptt) 2 ml citrated
plasma
rt daily sample must be
fresh
parvovirus (b-19) antibodies, igg, serum 1 ml serum rt 2 d
parvovirus (b-19) antibodies, igm, serum 1 ml serum rt 2 d
parvovirus (b19) dna, pcr edta whole
blood
frz 5 d
phenobarbital (luminal), serum 1 ml serum rt daily pre-dose
phenytoin, total, serum 1 ml serum rt daily pre-dose
philadelphia chromosome bcr/abl translocation, by fish (bone
marrow)
2 ml in heparin
tube
rt 3 d
phospholipid antibodies, igg, serum 1 ml serum rt 3 d
phospholipid antibodies, igm, serum 1 ml serum rt 3 d
phosphorus (inorganic), serum 1 ml serum rt daily
phosphorus, 24 hrs urine 5 ml of 24hr urine
or spot urine
rt daily
pku by tlc 1 ml edta
plasma
rt 4 d
plasminogen activator inhibitor 1, pcr 3 ml edta whole
blood
rt 4 d
platelets antibodies, serum 1 ml serum rt daily
polycystic kidney disease, autosomal dominant (pkd1, pkd2),
genetic analysis, pcr
edta whole
blood
rt 30 d
polycystic kidney disease, autosomal recessive (pkdh1), genetic
analysis, pcr
edta whole
blood
rt 30 d
porphyrines, fractionation (5 fractions by hplc) 10 ml 24 hr urine rt 3 d protect from light
porphyrines, total, quantitative 10 ml 24 hr urine rt 7 d in dark container
potassium, 24 hrs urine 5 ml of 24hr urine
or spot urine
rt daily
33
referral price list
test name sample type transport
conditions
tat notes
potassium, body fluid 5 ml of body
fluid
rt daily
potassium, serum 1 ml serum rt daily
pregnancy associated plasma protein-a (papp-a), serum 2 ml serum rt daily
prenatal first trimester screen 2 ml serum rt 2 d
prenatal maternal dual screen 2 ml serum rt daily
prenatal maternal quadruple screen 5 ml serum rt 4 d
prenatal maternal triple screen 2 ml serum rt daily
progesterone, serum 1 ml serum rt daily state day of
menstrual cycle
prograph (fk 506) 2 ml edta whole
blood
2-8oc daily
prolactin, serum 1 ml serum rt daily
prostatic-specific antigen (psa), free, serum 1 ml serum rt daily
prostatic-specific antigen (psa), total, serum 1 ml serum rt daily
protein c antigen assay, total 1 ml citrated
plasma
frz 2 d fresh sample
protein c functional level 1 ml citrated
plasma
frz 4 d
protein electrophoresis, csf 3 ml csf rt 4 d
protein electrophoresis, serum 1 ml serum rt 2 d
protein electrophoresis, urine 1 ml urine rt 2 d
protein s ag assay, total 2 ml citrated
plasma
frz 2 d fresh sample
protein s free, (antigen assay) 2 ml citrated
plasma
frz 4 d fresh sample
protein, total, 24 hrs urine 5 ml 24 hr urine
or spot urine
rt daily
protein, total, body fluids 2 ml body fluid rt daily
protein, total, cerebrospinal fluid 2 ml csf rt daily
protein, total, serum 1 ml serum rt daily
proteinase 3 (pr3) antibodies, serum 1 ml serum rt daily
prothrombin time (pt), plasma 2 ml citrated
plasma
rt daily sample must be
fresh
q
quadruple screen (maternal) 5 ml serum rt 4 d
34
referral price list
test name sample type transport
conditions
tat notes
r
random blood glucose, serum 1 ml serum rt daily
rapid plasma reagin (rpr) test, serum 1 ml serum rt daily
red blood cell inclusion bodies 1 ml edta whole
blood
rt daily
renin, plasma 1 ml edta
plasma
frz 7 d
respiratory syncytial virus (rsv) antibodies, igg, serum 1 ml serum rt daily
respiratory syncytial virus (rsv) antibodies, igm, serum 1 ml serum rt daily
reticulin antibodies, iga, serum 1 ml serum rt daily
reticulin antibodies, igg, serum 1 ml serum rt daily
reticulocyte count 1 ml edta whole
blood
rt daily
rheumatoid factor (rf) iga isotype, serum 1 ml serum rt 3 d
rheumatoid factor (rf) igg isotype, serum 1 ml serum rt 3 d
rheumatoid factor (rf) igm isotype, serum 1 ml serum rt 3 d
rheumatoid factor (rf), body fluids 1 ml synovial
fluids
rt daily
rheumatoid factor (rf), serum 1 ml serum rt daily
rickettsia antibodies, igg serum(weil-flex) 2 ml serum rt 3 d
rickettsia antibodies, igm serum(weil-flex) 2 ml serum rt 3 d
rotavirus, ag stool rt daily sample must be
fresh
rubella antibodies, igg, serum 1 ml serum rt daily
rubella antibodies, igm, serum 1 ml serum rt daily
s
saccharomyces cerevisiae antibodies, iga, serum 1 ml serum rt 3 d
saccharomyces cerevisiae antibodies, igg, serum 1 ml serum rt 3 d
salicylate, serum 1 ml serum rt daily
schistosoma (bilharzias) antibodies, serum 1 ml serum rt 2 d
seminal fluid analysis seminal fluid rt daily sample must be
fresh
sex hormone binding globulin (shbg), serum 1 ml serum rt daily fasting
35
referral price list
test name sample type transport
conditions
tat notes
sickle cell gene mutations, pcr 10 ml amniotic
fluid
rt 17 d
sickle cell gene mutations, pcr 3 ml edta whole
blood
rt 7 d
sirolimus (rapamycin), blood 2 ml edta whole
blood
rt 4 d do not separate
skeletal muscle antibodies, serum 1 ml serum rt daily
skin antibodies 1 ml serum rt daily
smooth muscle antibodies (asma), serum 1 ml serum rt daily
sodium, 24 hrs urine 5 ml of 24 hr
urine or spot
urine
rt daily
sodium, body fluids body fluids rt daily
sodium, serum 1 ml serum rt daily
sperm antibodies, serum 1 ml serum rt 3 d
sperm sex selection seminal fluid rt daily call lab
sperm wash, (iui) seminal fluid rt daily call lab
spinal muscular atrophy (sma), genetic analysis (smn1 & 2 genes),
amniotic fluid
amniotic fluid rt 30 d
spinal muscular atrophy (sma), genetic analysis (smn1 & 2 genes),
cvs
chorionic villus
sample
rt 30 d
spinal muscular atrophy (sma), genetic analysis (smn1 & 2 genes),
peripheral blood
2 ml edta whole
blood
rt 20 d
squamous cell carcinoma (scc) antigen, serum 1 ml serum rt daily
stone analysis renal stone rt 3 d
streptolysin o (aso) antibodies, serum 1 ml serum rt daily
striated muscle antibodies 1 ml serum rt daily
sudan iii stool rt daily sample must be
fresh
synovial fluid analysis 3 ml synovial
fluid
rt 2 d
t
tegretol, (carbamazepine), serum 1 ml serum rt daily draw blood predose
testosterone, free, serum 1 ml serum rt 2 d
testosterone, total, serum 1 ml serum rt daily
theophylline, serum 1 ml serum rt daily
36
referral price list
test name sample type transport
conditions
tat notes
thrombin antibodies 2 ml citrated
plasma
frz 3 d
thrombin time, plasma 2 ml citrated
plasma
rt daily sample must be
fresh
thyroglobulin antibodies, serum 1 ml serum rt daily
thyroglobulin, serum 1 ml serum rt daily
thyroid microsomal (atm) antibodies, serum 1 ml serum rt daily
thyroid peroxidase (tpo) antibodies, serum 1 ml serum rt daily
thyroid stimulating hormone (tsh), serum 1 ml serum rt daily
thyroxine (ft4), free, serum 1 ml serum rt daily
tissue transglutaminase abs, iga, serum 1 ml serum rt daily
tissue transglutaminase abs, igg, serum 1 ml serum rt daily
torch igg 5 ml serum rt daily
torch igg, igm 5 ml serum rt daily
torch igm 5 ml serum rt daily
total iron binding capacity (tibc), serum 1 ml serum rt daily
toxoplasma dna, pcr 2 ml edta
whole blood
rt 4 d vacutainer
toxoplasma gondii antibodies, igg, serum 1 ml serum rt daily
toxoplasma gondii antibodies, igm, serum 1 ml serum rt daily
tpo 1 ml serum rt daily
transferrin, serum 1 ml serum rt daily
treponema pallidum hemagglutination (tpha), serum 1 ml serum rt daily
trichomonas vaginalis, yeast & fungi, wet mount vaginal swab rt daily sample must be
fresh
triglycerides, serum 1 ml serum rt daily fasting
triiodothyronine (ft3), free, serum 1 ml serum rt daily
triple screen (maternal) 2 ml serum rt daily
trisomy 13 (pataus syndrome), fluorescent in situ hybridization amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d
trisomy 18 (edwards syndrome), fluorescent in situ hybridization amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d
37
referral price list
test name sample type transport
conditions
tat notes
trisomy 21 (downs syndrome), fluorescent in situ
hybridization
amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d
troponin i, serum 1 ml serum rt daily sample must be
fresh
troponin t, plasma 1 ml heparin
whole blood
rt daily sample must be
fresh
tsh receptor antibodies , serum 1 ml serum rt 3 d
u
urea, 24 hrs urine 5 ml 24 hr urine
or spot urine
rt daily
urea, serum 1 ml serum rt daily
uric acid, 24 hrs urine 5 ml 24 hr urine
or spot urine
rt daily
uric acid, serum 1 ml serum rt daily
uric acid, synovial fluid 1 ml synovial
fluid
rt daily
v
valproic acid, total, serum 1 ml serum rt daily pre-dose
vancomycin, serum 1 ml serum rt daily
vanilmandelic acid (vma), urine 30 ml 24 hr urine rt 3 d call lab
varicella zoster virus antibodies, igg, serum 1 ml serum rt daily
varicella zoster virus antibodies, igm, serum 1 ml serum rt daily
vdrl 1 ml serum rt daily
very low density lipoprotein (vldl) 1 ml serum rt daily fasting
vitamin a (retinol), serum 3 ml serum rt 3 d protect from light,
fasting, glass
tube
vitamin b1 (thiamine), blood 4 ml edta whole
blood
rt 3 d fasting, protect
from light
vitamin b12 (cyanocobalamine), serum 1 ml serum rt daily
vitamin b2 (riboflavin), blood 4 ml edta whole
blood
rt 3 d fasting, protect
from light
vitamin b6 (pyridoxine), plasma 2 ml serum or
heparinized
plasma
rt call lab
vitamin c (ascorbic acid) 2 ml heparin
whole blood
frz 3 d
vitamin d (25-hydroxycholecalciferol) total, serum 1 ml serum rt daily
38
referral price list
test name sample type transport
conditions
tat notes
vitamin e (alpha tocopherol), serum 2 ml serum rt 3 d fasting, protect
from light
vitamin h (biotin), serum 2 ml serum rt 3 d fasting, protect
from light
w
widal test (salmonella agglutinins), serum 2 ml serum rt 2 d
x
x,y chromosomes, fluorescent in situ hybridization amniotic fluid,
edta, li-heparin,
cvs media
rt 2 d
y
y chromosome microdeletions, pcr 3 ml edta whole
blood
rt 1 w
z
ziehl-nielsen (zn) stain for acid-fast bacteria corresponding
site
rt daily
zinc, serum 2 ml serum rt daily
zinc, urine 10 ml 24 hr urine rt daily
39
molecular genetics
introduction
in recent years, the field of medical genetics has been expanding our knowledge in
the involvement of genes and chromosomes with certain diseases and disorders. it is
now well established that genetic aspects are responsible for a variety of birth defects,
chronic diseases and a high percentage of mental retardation.
the molecular genetics laboratory at biolab provides comprehensive dna-based diagnostic
testing for a variety of genetic conditions and diseases, as well as prenatal diagnosis,
presymptomatic, predictive and carrier testing.
a new test, the quantitative fluorescent polymerase chain reaction (qf-pcr), has
been introduced to perform rapid prenatal diagnoses of common chromosome aneuploidies.
the clinical utility of this assay has repeatedly been confirmed together with
its high sensitivity and specificity in detecting major chromosome abnormalities. one of
the advantages of qf-pcr is the automation of part of the procedure that allows high
throughput of samples this makes rapid prenatal diagnosis available to all pregnancies
either as a tool to reduce parental anxiety while waiting for completion of fetal karyotype
or to improve pregnancy management in case of abnormal result.
the molecular genetics laboratory combines state-of-the art genetic testing run by a
team of qualified consultants, skilled specialized scientists working in a professional environment
dedicated to provide quality diagnostic services constantly aligned with the
rapidly growing field of laboratory medicine.
indications for molecular genetics testing
common reasons for referral of molecular genetic tests
thrombosis screen
• for the evaluation of inherited thrombotic risk within families.
• transient ischemic attack or premature stroke
• hyperhomocysteinemia, low plasma folate levels.
• prior to pregnancy, oral contraceptive prescription, estrogen therapy or major surgery if there is
a family history of thrombosis
• recurrent abortion.
single gene disorders
1. recessive disorders
e.g. cystic fibrosis, familial mediterranean fever, hereditary hemochromatosis, spinal muscular
atrophy
• carrier testing and risk assessment in families
specialties
40
2. dominant disorders
e.g. osteogenesis imperfecta
• confirmation or exclusion of a diagnosis
3. x – linked disorders
e.g. duchenne muscular dystrophy, fragile x syndrome
• carrier testing and risk assessment in families
fertility testing
e.g. y- chromosome microdeletions, cystic fibrosis
• azoospermia
• confirmation or exclusion of a diagnosis
• carrier testing and risk assessment in families
hemoglobinopathies
e.g. alpha-thalassemia, beta-thalassemia, sickle cell anemia
• carrier testing and risk assessment in families
tissue typing and rh genotyping
• organ transplant
• maternal-fetal rh incompatability which can cause alloimmune hemolytic disease in the fetus or new born.
oncology
e.g. breast cancer genes 1 and 2 (brca1 and brca 2), philadelphia chromosome bcr/abl translocation
• carrier testing and risk assessment in families
• presymptomatic testing in individuals at risk of late-onset genetic disorder (patient may present positive
family history or positive preliminary testing).
prenatal testing
prenatal diagnosis is available for the following genetic disorders:
• cystic fibrosis
• ?-thalassemia
• ?-thalassemia
• sickle cell anemia
• duchenne and becker muscular dystrophies
• fragile x syndrome
• spinal muscular atrophy
• amniopcr by qf-pcr for aneuploidy screening of chromosomes 13,18, 21, x, and y
amniopcr by qf-pcr (quantitative fluorescent polymerase chain reaction)
• amniopcr by qf-pcr is a rapid screening for the detection of aberrant copy numbers of human
chromosomes 13, 18, 21, x and y in small uncultured amniotic fluid samples. this is not equivalent to a full
chromosome analysis and is always followed by a full karyotype.
• amniopcr by qf-pcr can be undertaken for rapid sexing on amniot ic fluid. useful when suspecting
turner syndrome, or where there is a risk of sex linked single gene disorders.
limitations of molecular genetics testing
• reliable results are dependent on adequate sample collection, transport, storage and processing
procedures.
• prenatal diagnosis is af fected by mater nal cell contamination in amniotic fluid and may ther efore
complicate the interpretation of test results.
• on rare instances, technical limitations associated with some of the technologies used may be present.
• the diagnostic efficiency of the test can be impeded by drug interference.
• heparin inhibits the pcr reaction, therefore samples collected in heparin tubes will be rejected and a
repeat assay requested.
41
molecular genetics tests
genetic tests specimen sample turn around
time
amnio pcr for aneuploidy screening of chromosomes 13, 18, 21, x and y,
qf-pcr
amniotic fluid 2 – 3 days
cardio vascular disease risk factors, 12 mutations profile, pcr edta whole blood 7 days
cystic fibrosis cftr gene mutations (36 mutations), amniotic fluid amniotic fluid 17 days
cystic fibrosis cftr gene mutations (36 mutations), blood edta whole blood 7 days
cystic fibrosis cftr gene mutations (36 mutations), cvs chorionic villus sampling
(cvs)
17 days
duchenne and becker muscular dystrophy (dmd,bmd), genetic analysis edta whole blood 18 – 20 days
duchenne and becker muscular dystrophy (dmd,bmd), genetic analysis amniotic fluid 30 days
duchenne and becker muscular dystrophy (dmd,bmd), genetic analysis chorionic villus sampling
(cvs)
30 days
factor ii g20210a prothrombin gene mutation (for cvd and recurrent
abortion)
edta whole blood 4 days
factor v g1691a (leiden) gene mutation ( for cvd and recurrent abortion)
edta whole blood 4 days
familial mediterranean fever (12 mutations) edta whole blood 4 days
hereditary hemochromatosis hfe gene mutations (h63d, s65c, c282y),
pcr
edta whole blood 4 days
hla abc, blood, pcr edta whole blood 7 days
hla b27, blood, pcr edta whole blood 4 days
hla b5, blood, pcr edta whole blood 4 days
hla dr, blood, pcr edta whole blood 4 days
human oncogenes, breast cancer genes (brca1, brca2), gene analysis,
pcr
edta whole blood 3 weeks
jak2 - gene - val617phe (v617f) mutation - whole blood edta whole blood 3 days
microdeletion syndromes – (amniotic fluid, whole blood) amniotic fluid, whole blood 21 days
mthfr c677t (for cvd and recurrent abortion) edta whole blood 4 days
pca3 - gene - prostate cancer marker - messenger rna detection transport tubes are provided
upon request
30 working days
polycystic kidney disease – autosomal dominant (pkd1, pkd2) edta whole blood 30 days
genetic tests specimen sample turn around
time
polycystic kidney disease – autosomal recessive (pkdh1) edta whole blood 30 days
spinal muscular atrophy (sma), genetic analysis edta whole blood 18 – 20 days
spinal muscular atrophy (sma), genetic analysis amniotic fluid 30 days
42
spinal muscular atrophy (sma), genetic analysis chorionic villus sampling
(cvs)
30 days
y chromosome microdeletions (6 deletions), pcr edta whole blood 7 days
?-globin gene, ?-thalassemia, (21 mutations), pcr, amniotic fluid amniotic fluid 7 days
?-globin gene, ?-thalassemia, (21 mutations), pcr, blood edta whole blood 7 days
?-globin gene, ?-thalassemia, (21 mutations), pcr, cvs chorionic villus sampling
(cvs)
7 days
?-globin gene, ?-thalassemia, (22 mutations), pcr, amniotic fluid amniotic fluid 17 days
?-globin gene, ?-thalassemia, (22 mutations), pcr, blood edta whole blood 7 days
?-globin gene, ?-thalassemia, (22 mutations), pcr, cvs chorionic villus sampling
(cvs)
17 days
43
microbial genetics
introduction
emerging infections are attracting greater attention from the public health and medical
communities. pathologists and other physicians are increasingly aware of the importance
of the subspecialty of infectious disease pathology as a tool for diagnosis, monitoring therapy
and prognosis as well as research of emerging infections.
in view of the progress in the science of molecular biology, the applications of diagnostic
microbial genetics has taken a major role in the way clinicians manage their patients utilizing
an array of technologies such as pcr, rt-pcr, and gene sequencing.
the microbial genetics laboratory provides a list of essential molecular bacteriological and
viral tests that can detect, quantify and genotype these pathogenic organisms.
indications for microbial genetics testing
common reasons for referral of microbial genetic tests
• confirm or exclude a diagnosis of an infectious disease
• monitor viral load in established infected individuals and evaluate the efficacy of antiviral treatment
• assess reactivation of infection in transplant patients and evaluate potential disease transmission from
prospective donors to tissue transplant recipients
• diagnosis of sexually transmitted diseases
limitations of microbial genetics testing
• reliable results are dependent on adequate sample collection, transport, storage and processing
procedures.
• heparin inhibits the pcr reaction, therefore samples collected in heparin tubes will be rejected and
a repeat assay requested.
• any diagnostic test has its limits with regards to sensitivity and detection limit.
• in rare instances, the diagnostic efficiency of some tests can be impeded by drug interference.
genetic tests specimen sample turn around
time
qualitative assays
h1n1 influenza virus rna nasal swabs, nasopharyngeal
swabs, serum, plasma
4 days
mycobacterium tuberculosis body fluids 4 days
herpes simplex virus i &ii dna body fluids, swabs 4 days
human papilloma virus dna genotyping body fluids, swabs, warts 4 days
chlamydia trachomatis body fluids, swabs 4 days
neisseria gonorrhea body fluids, swabs 4 days
quantitative assays
hepatitis c virus rna, quantitative serum 4 days
hepatitis c virus rna, genotyping serum 4 days
hepatitis b virus dna, quantitative serum 4 days
44
cytogenetics
introduction
cytogenetic techniques allow for the unambiguous identification of each human chromosome
and the detection of aneuploidy and many large structural rearrangements that
cause physical and / or mental retardation, congenital anomalies related to inherited conditions,
abnormal sexual development, and other defects. new techniques allow for increased
resolution of chromosome banding patterns, permitting differentiation of a greater
number of abnormalities. fluorescent in situ hybridization (fish) technique (using chromosome-
gene- or translocation- specific dna probes) is used in the detection of genetically
important trisomies, diagnosis and classification of various neoplasia and hematological
malignancies as well as prenatal and pre-implantation diagnosis.
the department’s activities fall into three main sectors, namely prenatal diagnosis (amniotic
fluid, fetal blood, chorionic villus samples, product of conception, fetal biopsies), constitutional
cytogenetics (peripheral blood) and onco-hematological cytogenetics (bone
marrow, lymph nodes, solid tumors, and pleural effusions).
indications for cytogenetics testing
chromosomal karyotyping
post-natal blood cytogenetics testing
• dysmorphology/multiple congenital abnormalities suggestive of a chromosome abnormality
• ambiguous genitalia/indeterminate gender
• unexplained learning difficulties/developmental delay
• delayed puberty, gynecomastia or inappropriate secondary sexual development
• short stature, amenorrhea in females
• oligospermia or azoospermia in males
• parental karyotyping after two or more unexplained pregnancy loss.
• parental karyotyping after pregnancy loss of an unkaryotyped fetus with multiple congenital abnormalities
or intrauterine growth restriction (iugr)
• family history (first degree relatives) of a known chromosome abnormality other than simple aneuploidy
due to non-disjunction
• suspected family history of chromosome abnormality where the karyotype of the affected individual is
not known
• conditions such as growth failure, microcephaly, neurological abnormalities, immunodeficiency, and an
increased incidence of malignancy
postnatal cytogenetic testing on skin biopsies and other tissues
• karyotyping of skin biopsy or other types of tissues from a live patient is usually performed to investigate
the possibility of tissue-specific chromosomal mosaicism. this is usually undertaken once a karyotyping
has been obtained on a blood sample.
prenatal cytogenetic testing (amniotic fluid, chorionic villus sampling)
• high risk of carrying fetus with chromosomal abnormality that may have been detected as a result of
a screening test (first or second trimester screen).
45
• intracytoplasmic sperm injection (icsi) or other medical intervention that increases the probability of
chromosome abnormalities.
• abnormal ultrasonographic findings indicative of chromosome abnormality.
• history of chromosome abnormality indicative of increased risk for future pregnancies (chromosome
abnormalities in either parent, a previous pregnancy or the family history)
• augmented nuchal translucency
cytogenetic testing of fetal/placental tissue after pregnancy loss
• any fetus, stillbirth or neonatal death with congenital abnormality suggestive of a chromosome anomaly
or with neural tube defect or with intrauterine growth restriction (iugr).
• unexplained stillbirth or spontaneous abortion.
• determine recurrence risk for future pregnancy losses.
fluorescent in situ hybridisation (fish)
rapid neonatal aneuploidy screening by fish
• rapid neonatal screening by fish for trisomies 13, 18 and 21 and for sex. this is not equivalent to a full
chromosome analysis and is always followed by a full karyotyping.
cytogenetic testing of bone marrow and unstimulated blood
• chronic lymphocytic leukemia (cll)
• acute lymphocytic leukemia (all)
• acute myeloid leukemia (aml)
• myelodysplastic disorder (msd)
• multiple myeloma (mm)
• lymphoma
• cytopenia
cytogenetic testing of solid tumors
• ewing sarcoma
• neuroblastoma
• lymphoma
• hepatoblastoma
• germ cell tumor
• rhabdomyosarcoma
• synovial sarcoma
• breast carcinoma
limitations of cytogenetics testing
small subtle chromosome abnormalities
• cytogenetic analysis relies on g-band quality and resolution. in general, blood samples give the best
quality chromosomes and therefore provide the best chance of detecting small subtle chromosome
abnor malities. chromosomes from other tissues (e.g. amniotic fluid, chorionic villus and pr oducts of
conception) give poorer quality chromosomes hence the risk of missing a subtle abnormality is
increased.
• it should be noted that on rare occasions a subtle abnormality may be missed at prenatal diagnosis,
only to be diagnosed later on a postnatal blood sample.
• it should also be understood that even a g-band blood karyotype can never exclude extremely subtle
chromosome abnormalities that are at the limit of resolution of light microscopy.
46
detection of mosaicism
• it is well established that although mosaicism may be detected by routine karyotyping it can never be
100% excluded. however, if there is an indication of suspected mosaicism, additional cells will be examined
to exclude 10% mosaicism at a 95% confidence level.
interpretation of mosaicism in prenatal diagnosis
• true mosaicism, when detected prenatally, can be difficult to interpret and a further invasive diagnostic
test may be required. mosaic cell lines may be unevenly distributed between the fetus and extra-fetal
tissues leading to false positive and false negative results in the most extreme cases. ‘confined placental
mosaicism’ (cpm) is observed in approximately 1-2% of cvs samples.
• pseudomosaicism can arise as an artifact of culture and is not representative of the fetal karyotype.
this is normally present in only one of two or three independently established cultures and can therefore
be interpreted accordingly. in most cases, no further invasive testing is required.
maternal cell contamination in prenatal diagnosis
• maternal cell contamination of chorionic villus and amniotic fluid occurs in approximately 1/250 samples
and may occasionally complicate the interpretation of results.
normal variation
• each chromosome pair has a specific and identical g-banding pattern in all individuals. however, variation
may occur around the centromeric regions and short arms of some chromosomes that is of no clinical
significance. these variations are known as ‘polymorphic variants’, ‘polymorphisms’ or ‘normal variants’.
• in a few cases, it is necessary to distinguish between such variation and a true abnormality. it may therefore
be necessary to karyotype the parents or to carry out further tests on a repeat sample.
on rare instances, technical limitations associated with some of the technologies used may be present.
cytogenetics tests
karyotyping requirements
specimen quantity container maximum transit
time
turnaround
time
peripheral blood 2 – 4 ml li-heparin bottle (sterile, vacutainer, plastic) 48 hours 7 days
fetal blood/cord 0.5 – 1 ml li-heparin bottle (sterile, plastic) 48 hours 7 days
bone marrow and
unstimulated blood
2 - 5 ml li-heparin bottle (sterile, plastic) 24 hours 5 days
amniotic fluid 15 – 20 ml universal container or 16 ml conical tube (sterile,
plastic)
24 hours 14 days
chorionic villus
sampling
2 - 25 mg universal container (sterile, plastic). in sterile
media.
24 hours 14 days
products of
conception
variable universal container (sterile, plastic). in sterile
saline.
24 hours 14 days
fetal tissue/skin 1 cm3 universal container (sterile, plastic). in sterile saline 48 hours 14 days
fragile x 2 - 4 ml li-heparin bottle (sterile, vacutainer, plastic) 48 hours 7 days
chromosomal
breakage (fanconi›s
anemia)
2 - 4 ml li-heparin bottle (sterile, vacutainer, plastic) 48 hours 7 days
47
fish requirements
tests quantity container maximum transit
time
average turnaround
time
amniotic fluid, blood, chorionic villus sampling (cvs)
trisomy 13 [patau syndrome]
3 ml
amniotic fluid in universal container or
conical tube, (sterile, plastic)
li-heparin bottle / edta whole blood (sterile,
plastic)
cvs in media (sterile, plastic)
within
24 hours 1 - 2 working days
trisomy 18 [edward’s
syndrome]
trisomy 21 [down’s
syndrome]
rapid sexing ( x and y )
prader willi
digeorge
miller dieker
trisomy 21, xy
trisomy 13, 18 and 21
trisomy 13, 18, 21 and
xy
preimplantation genetic diagnosis (pgd)
pgd fixated
blastomere
salinated slide n/a within 24 hours
bone marrow and unstimulated blood
bcr/abl: t(9 22) [cml/
all]
1 - 2 ml li-heparin bottle (sterile, plastic) 24 hours 2 - 3 days
gli: (12q13) [cll]
atm: (11q22) [cll]
p53: (17p13) [cll]
dleu: 13q14 [cll]
eto/aml: t(8 21) [aml/
m2]
cbfb: inv(16) [aml/m4]
pml/rara: t(15 17)
[aml/m3]
tel/aml: t(12 21) [all]
mll: 11q23 [all/aml]
deletingd q5: [mds]/
[aml]
deletingd q7: [mds]/
[aml]
48
tests quantity container maximum transit
time
average turnaround
time
lsi/myc: t(8q24) [burkitt
lymphoma] (screening)
1 - 2 ml li-heparin bottle (sterile, plastic) 24 hours 2 - 3 days
myc/igh: t(8 14) [burkitt
lymphoma]
bcl1/igh: t(11 14)
[mantle cell lymphoma]
igh/bcl2: t(14 18) [follicular
lymphoma]
lsi/alk: t(2p23)
[anaplastic large cell
lymphoma]
bone marrow and unstimulated blood
her-2: [breast carcinoma]
n/a paraffin embedded block n/a 3 – 5 days
ewsr: [ewing sarcoma]
n-myc: [neuroblastoma]
fkhr: 13q14 [alveolar
rhabdomyosarcoma]
syt: 18q11.2 [synovial
sarcoma]
49
sperm wash (iui)
sperm washing is a procedure used to prepare sperm for use in intrauterine insemination (iui), which is the
placement of sperm in the uterus for the purpose of enhancing the chance for pregnancy. preparation for an
iui involves separation of the sperm from the seminal fluid. the semen sample must be washed free of debris,
white blood cells, and prostaglandins, which can cause the uterus to contract. the processing also removes
dead sperm and concentrates the sperm into a small volume that can easily be handled by the uterus. this
procedure is usually done in cases of unexplained infertility, male-factor infertility, women with endometriosis,
men with antisperm antibodies, or men that are hiv positive.
special requirements
• collect seminal fluid in special container provided.
• 3 days abstinence from intercourse is preferred.
• avoid samples older than 1 hour.
• proper patient history required.
• results are provided in the same day.
• sperm wash’s referral price is of 25jod.
50
indications for autoimmune testing
the cause of autoimmune diseases is unknown, but it appears that there is an inherited predisposition to develop
autoimmune disease in many cases. in a few types of autoimmune disease (such as rheumatic fever),
a bacteria or virus triggers an immune response, and the antibodies or t-cells attack normal cells because
they have some part of their structure that resembles a part of the structure of the infecting microorganism.
autoantibodies may be present in healthy individuals and may also occur transiently with intercurrent illness
or may be induced by drug therapy.
limitations of autoimmune testing
the interpretation of all autoantibody tests is highly dependent on the likelihood of disease in the patient. the
results should always be interpreted with the clinical features of the patient and never in isolation. autoantibodies
may be present in healthy individuals and may also occur transiently with intercurrent illness or may be
induced by drug therapy. conversely, autoimmune disease may be present in the absence of detectable
autoantibodies. do not use these tests as ‘screens’ for autoimmune disease but rather decide the clinical
diagnosis and the likelihood of autoimmune disease, then use specific autoantibody tests as diagnostic aids.
on rare instances, technical limitations associated with some of the technologies used may be present.
autoimmunity
introduction
the incidence of autoimmune diseases is increasing worldwide and it represents the third
cause of morbidity in developed countries (after cardiovascular disease and cancer). the
search for better management of these diseases and even for a cure is being pursued by
scientists from many disciplines. tools from the areas of genetics, neuroscience, cell biology,
virology, and infectious disease are being applied to the problem and are yielding
useful results. biolab strives to be in the forefront of development of new tests and technologies
that aid in the diagnosis of autoimmune disease.
any molecule in the body may act as an auto-antigen and induce an autoimmune reaction,
meaning that the range of possible auto-antibodies to be sought is substantial. autoimmune
disorders fall into two general types: those that damage many organs (‘systemic’),
and those where only a single organ or tissue is directly damaged by the autoimmune
process (‘localized’). in some pathological situations, auto-antibodies are extremely sensitive
markers which can be detected months or even years before the onset of symptoms.
the immunology department at biolab can assay for many different auto-antibodies, including
some that are rare or were only recently characterized. auto-antibodies can be
detected either by indirect immunofluorescence on cell smears (transfected hep2 cells,
neutrophils) or tissue sections (pancreas, kidney, esophagus, etc.), or directly by elisa,
whereas others can be typed by immunoblotting.
51
immunology department
autoimmune testing
test name specimen
sample
turn around
time
acetylcholine receptor abs
serum 1 day
anca-gbm abs (myeloperoxidase (mpo), proteinase 3 (pr3), glomerular basement membrane)
anti centromere abs
anti double stranded dna abs (dsdna)
anti ena abs (sm, rnp, ss-a, ss-b, jo1, ssdna, histones, nucleosomes, ribosomal p-protein)
anti endomysium abs iga/igg
anti ganglioside abs (gm1, gm2, gm3, gd1a, gt1b,gd1b, gq1b)
anti glutamate decarboxylase abs 65 (gad ii)
anti langerhans cell abs
anti mitochondrial abs (ama) m2
anti mullerian hormone – amh
anti myelin abs
anti myelin-associated glycoproteins abs - mag
anti neuronal nuclear abs ( anti-hu (anna1), anti-yo (pca1), anti-pnma2 (ma/ta), anti-ri
(anna2), anti-amphiphysin)
anti neutrophil cytoplasm abs (p-anca, c-anca)
anti nuclear abs (ana)
anti ovarian abs
anti parietal cell abs
anti platelets abs
anti skeletal muscle abs
anti smooth muscle abs (asma)
anti transglutaminase abs iga/igg
liver antigen profile – lag (ama-m2, lkm-1, sla/lp, lc-1)
*this price is per immunoglobulin.
52
systemic autoimmune disorders
autoimmune diseases related tests
disseminated lupus erythematosus • anti nuclear abs (ana)
• anti double stranded dna abs (dsdna)
• anti ena abs (sm, rnp, ss-a, histones,
nucleosomes, ribosomal p-protein)
sj?gren s syndrome • anti nuclear abs (ana)
• anti ena abs (ss-a, ss-b)
drug induced lupus erythematosus • anti nuclear abs
• anti ena abs (histones)
neonatal lupus erythematosus • anti ena abs (ss-a)
mixed connective tissue disease • anti nuclear abs (ana)
• anti ena abs (rnp)
• anti single stranded dna (ssdna)
polymyositis, anti-synthetase syndrome • anti nuclear abs (ana)
• anti ena abs (jo1)
systemic scleroderma • anti nucleoli abs
• anti ena abs (scl-70)
crest syndrome (calcinosis, raynaud’s phenomenon, esophageal dysfunction,
sclerodactyly, telangiectasia)
• anti centromere abs
antiphospholipid syndrome • anti cardiolipin abs igg/igm
• lupus anticoagulant
• anti b2 glycoprotein 1 abs igg/igm
rhumatoid polyarthritis • anti rheumatoid factors abs igm
• anti citrullinated peptides abs
• anti ena abs (histones, ssdna)
localized autoimmune disease (pancreas)
autoimmune diseases related tests
insulin dependent diabetes • anti langerhans cell abs
• anti glutamate decarboxylase abs 65
(gad ii)
• anti tyrosinephosphatase abs
autoimmune pancreatitis • anti insulin abs
• anti lactoferrine abs + carbonic anhydrase
53
localized autoimmune disease (liver)
autoimmune diseases related tests
primary biliary cirrhosis • anti mitochondrial abs (ama) m2
type 1 autoimmune hepatitis • anti smooth muscle abs (asma)
• anti actin abs (f-actin) – main component of
the broad family of smooth muscle antibodies
• anti soluble liver abs (sla)
type 2 autoimmune hepatitis • anti liver kidney microsome (lkm)
• anti cytosol abs (lc1)
primary sclerosing cholangitis • anti polynuclear neutrophil cytoplasm abs
(p-anca)
localized autoimmune disease
(inner ear)
autoimmune diseases related tests
cogan syndrome • anti cochlea abs
meniere disease • anti collagen type ii abs
localized autoimmune disease (eye)
autoimmune
diseases
related tests
retinitis, keratitis, uvetitis • anti retina, cornea,crystallin abs
54
localized autoimmune disease (intestines)
autoimmune diseases related tests
celiac disease = gluten
intolerance
• anti transglutaminase abs iga/igg
• anti endomysium abs iga/igg
• anti gliadin abs iga/igg
• anti reticulin abs iga/igg
crohn • anti saccharomyces cerevisiae abs iga/
igg (asca)
hemorrhagic rectocolitis • anti polynuclear neutrophil cytoplasm
abs (p-anca)
localized autoimmune disease
(adrenal, ovaries)
autoimmune diseases related tests
addison • anti cortico-adrenal abs
• anti 21 hydroxylase abs
premature menopause hypofertility
• anti testicular abs
• anti ovary abs
localized autoimmune disease (thyroid)
autoimmune diseases related tests
basedow • anti tsh receptor abs (trab)
hashimoto thyroiditis primary
myxoedea
• anti thyroperoxidase abs (tpo)
• anti thyroglobulin abs (ath)
• anti microsomes thyroid abs (atm)
55
localized autoimmune disease (skin)
autoimmune diseases related tests
pemphigus • anti intracellular substance abs - desmosomes
• anti desmoglein 1+3 abs
bullous pemphigoid • anti epidermal basal membrane abs
herpes gestationis • anti bp180 abs
herpetiform dermatitis • anti transglutaminase abs iga/igg
• anti endomysium abs iga/igg
subacute cutaneous lupus • anti ena abs (ss-a)
localized autoimmune disease (kidney, lung)
autoimmune diseases related tests
goodpasture syndrome • anti glomerular basement membrane
abs (gbm)
wegener • anti neutrophil cytoplasmic abs
(proteinase 3 abs – pr3, c-anca)
microscopic polyangiitis extra capillary
glomerulonephritis
• anti neutrophil cytoplasmic abs (myeloperoxidase
abs – mpo, p-anca)
localized autoimmune disease (cartilage)
autoimmune diseases related tests
polychondritis • anti collagen type ii abs
56
localized autoimmune disease
(nervous system)
autoimmune diseases related tests
myasthenia • anti acetylcholine receptor abs (acr)
• anti muscle-specific kinase abs (musk)
• anti striated muscle abs
• anti titin abs
lambert eaton syndrome • anti calcium channel abs
stiffman syndrome • anti glutamate decarboxylase abs 67 (gad i)
• anti amphiphysin abs
isaac syndrome • anti potassium chanel abs
peripheral neuropathies • anti myelin abs
• anti mag abs
• anti sulfatide abs
• anti gangliosides abs igg/igm
devic disease • anti neuromyelitis optica abs
paraneoplastic syndromes • anti neuronal abs (anna)
57
localized autoimmune disease (parathyroid)
autoimmune diseases related tests
hypoparathyroid • anti parathyroid abs
• anti calcium sending receptor abs
localized autoimmune disease
(stomach)
autoimmune diseases related tests
type a gastritis • anti intrinsic factor abs
• anti parietal cell abs
• anti h+k+atpase abs
58
indications for serology testing
serological tests can be used to screen for or diagnose viral, fungal and parasitic infectious diseases, and
assess the subject’s immune status which is of particular importance to pregnant women and the immunodeficient.
the serologic indirect techniques by quantification of antibodies have extremely been useful in the diagnosis
and the therapeutic or vaccination follow-up.
serological tests are performed to detect current, active, or past infections in people who are at risk for reactivation
of infection (such as organ transplant recipients and people with a suppressed immune system).
the presence of antibodies to certain infectious diseases indicates a current or past infection. if the number of
antibodies rises over a few weeks, it may mean that one has an acute infection. chronic infection (in which
the antibody count stays about the same over time) can reactivate in a person with a suppressed immune
system.
limitations of serology testing
the results require in the majority of the cases to be compared on two subsequent serum samples, to observe
a possible increase in antibodies level. in addition, the infectious serology results may not be considered as
the only element of final diagnosis. in all cases, they have to be interpreted and challenged against the
clinical context. results may reveal hard to interpret, especially when the scope is to specify the time of the
beginning of an infection.
infectious serology
introduction
biolab has taken a further step towards serving laboratory services in jordan stemming
from our commitment to ‘where health matters’, we have extended its menu and assembled
a range of techniques in the immunology department. the department covers a wide
range of tests from immunoenzymatic methods such as elisa and indirect immunofluorescence,
to direct immunofluorescence, particle agglutination, hemagglutination, complement
fixation, western blotting and immunoelectrophoresis.
the various techniques used, enable us to both quantify humoral responses and characterize
the isotype of the antibody in question (igg, iga or igm) when necessary. these methods
can be applied to antibodies against viruses (hiv, hcv, ebv), bacteria (lyme disease,
syphilis, etc.), parasites (both local—echinococcus infection and toxocariasis—and tropical—
amoebiasis and schistosomiasis) and fungi (notably candida albicans and aspergillus
fumigatus).
59
serology
infectious virology
test name specimen
sample
turn around
time
adenovirus iga, igg, igm
serum 1 day
coxsakie virus (a7, 9, 16 & 24) igg, igm
coxsakie virus (b1 - 6) igg, igm
cytomegalovirus igg, igm
epstein barr virus(ebv-vca) igg, igm
herpes simplex virus type i & ii igg, igm
herpes simplex virus type i igg, igm
herpes simplex virus type ii igg, igm
influenza virus a igg, igm
influenza virus b igg, igm
measles virus igg, igm
mumps virus igg, igm
respiratory syncitial virus igg, igm
rubella virus igg, igm (german measles)
varicella zoster virus igg, igm (chicken pox)
infectious bacteriology/parasitology
borrelia burgdorferi igg, igm (lyme disease)
serum 1 day
coxiella burnetii igg, igm
chlamydia igg, igm
helicobacter pylori igg, iga
legionella igg, igm
mycoplasma igg, igm
toxoplasma igg, igm
*this price is per immunoglobulin.
60
cytology
introduction
stemming from our commitment to ‘where health matters’, we have introduced the cytology
department. this traditional medical discipline is based on the microscopic examination
of diseased cells, and plays a key role in the diagnosis and treatment of diseases,
notably cancers.
cervical cytology, one of the department’s fields of expertise, has been perhaps the most
successful cancer screening technique of the 20th century. worldwide, cervical cancer is
the second most common cancer in women (following breast cancer) it ranks first in many
developing countries lacking screening programs. the success of cervical cytology screening
lies in its relative simplicity, low cost and non-invasive nature. annual screening reduces
the probability of developing invasive carcinoma by over 95%.
indications for cytology testing
risk factors for cervical cancer
•human papillomavirus (hpv)
•immunosuppressed or immunodeficient
•co-factors such as:
•combined oral contraceptives (cocs)
•smoking
•number of sexual partners
•age at first intercourse
•failure to attend regular cervical screening checks
risk factors for nipple secretions
•breast abscess
•breast cancer
•choriocarcinoma
•intraductal papilloma
•mammary duct ectasia
•paget’s disease
•prolactin-secreting pituitary tumor
•proliferative (fibrocystic) breast disease
risk factors for pulmonary lesions
•infectious granuloma
•infectious lung diseases caused by fungus
•lung abscess
•lung cancer
61
risk factors for fine needle aspirations
•palpable nodule in the thyroid gland, enlarged thyroid or abnormal cervical nodes.
•hypoechoic.
•irregular borders.
•intranodal vascularity.
•microcalcifications >1 cm or increasing in size.
•history of radiation exposure.
risk factors for urine cytology
•patients with symptomatic microscopic hematuria.
•asymptomatic microscopic hematuria in patients > 40 years old or younger patients with risk factors for
urological cancer.
•the follow up of patients who have been treated for bladder cancer.
•as a secondary investigation in frank hematuria.
limitations for cytology testing
limitations for pap smear
the actual amount of time spent analyzing a given slide is highly variable. factors influencing the amount
of time spent examining a cervical cytology slide include method of sample preparation (liquid based vs.
conventional), overall sample cellularity, blood, inflammation or other obscuring factors, clinical history,
complexity of findings and the cytologist’s experience and state of mind.
limitations for fine needle aspiration
though this procedure allows a minimally invasive, rapid diagnosis of tissue but does not preserve its histological
architecture. in some cases this limits the ability to make a definitive diagnosis. as with any invasive
procedure there are risks, and as with all diagnostic tests involving sampling and interpretation, important
diagnoses can be missed.
limitations for urine cytology
false-negative test results generally are attributed to inability to sample some lesions (eg, voided urine
specimens may not contain shed neoplastic cells) or to difficulties in diagnosing some entities (eg, lowgrade
cancers cytologically resemble nonneoplastic urothelium). false-positive test results often are attributed
to mimics (eg, polyoma virus).
62
cytology tests requirements
test specimen container temperature maximum
transit time
average
turnaround time
urgent routine
smear:
pap cervical vault
slide fixed in 96% ethanol rt 24 hrs within 24
hrs
1-2 days
discharge:
vaginal nipple
slide fixed in 96% ethanol rt 24 hrs within 24
hrs
1-2 days
fna :
thyroid lymph node breast
slide fixed in 96% ethanol rt
24 hrs 1-2 days 2-3 days
fluid syringe 2 – 8oc
fluid :
ovarian cyst intraperitonial
pericardial pleural
synovial
slide fixed in 96% ethanol rt
24 hrs 1-2 days 2-3 days
fluid syringe
bag
2 – 8oc
bronchial lavage fluid bag 2 – 8oc 24 hrs 1-2 days 2-3 days
sputum
(deep cough)
slide fixed in 96% ethanol rt
24 hrs 1-2 days 2-3 days
fluid cup 2 – 8oc
cerebrospinal fluid
(csf) fluid syringe
2 – 8oc
24 hrs 1-2 days 2-3 days
urine voided urine bag 2 – 8oc 24 hrs 1-2 days 2-3 days
63
biomnis test list
test name
10-hydroxy-carbazepine - serum
11-deoxycorticol - compound s - serum
11-deoxycorticol - compound s - urine
11-deoxycorticosterone - serum
17-hydroxy-corticosteroids - fractioning - urine
17-hydroxy-corticosteroids - urine
17-hydroxy-pregnenolone - serum
17-ketosteroids - fractioning - urine
17-ketosteroids - urine
18-hydroxycorticosterone - serum
18-hydroxydesoxycorticosterone - serum
1-methylhistidine - plasma
1-methylhistidine - urines
21-deoxycortisol - serum
2,5-hexanedione - urines
3-alpha-androstanediol glucuronide - serum
3-alpha-androstanediol glucuronide - urines
3-alpha-androstanediol - urine
3-hydroxybenzo[a]pyrene - benzo[a]pyrene metabolite - urines
3-methylhistidine - plasma
3-methylhistidine - urines
4,4 -methylenedianiline - urines
5-hiaa - 5-hydroxyindoleacetic acid - plasma
test list
64
biomnis test list
test name
5 -nucleotidase - activity - serum
abacavir - plasma
abo blood grouping - rhesus - whole blood
abo system immune antibodies - anti-a - screening and titration - serum
abo system immune antibodies - anti-b - serum
acebutolol - serum
acetone - - - urines
acetone - whole blood
acetylcholine esterase - amniotic fluid
acetylsalicylic acid - serum
aciclovir - plasma
acid hydrolases - activity - serum
acid phosphatases - seminal plasma
acid phosphatases tartrate-labile - serum
acylcarnitine – blotting paper
adefovir - plasma
adenosine deaminase - ada
adenovirus - orientated culture
adenovirus - presumptive diagnosis
african haemorrhagic fevers - serum
alad - aminolevulinate dehydratase - whole blood
albumin - aspiration biopsy
albumin - csf
65
biomnis test list
test name
aldosterone - urines
alimemazine - serum
alloisoleucine - plasma
alloisoleucine - urines
alpha-1 antitrypsin - clearance
alpha-1 antitrypsin - s and z variant genotyping - whole blood
alpha-1 microglobulin - urines
alpha-2 antiplasmin - activity - plasma
alpha-2 macroglobulin - serum
alpha-alanine - plasma
alpha-alanine - urines
alpha-aminoadipic acid - plasma
alpha-aminoadipic acid - urines
alpha-aminobutyric acid - plasma
alpha-aminobutyric acid - urines
alpha-glucosidase - seminal plasma
alpha-glutathione s-transferase - serum
alpha hbdh - alpha-hydroxybutyrate dehydrogenase - serum
alpha subunit - hcg, fsh, lh, tsh - serum
alprazolam - serum
aluminium - urine
aluminium - water - hospital infection control
amh - anti-müllerian hormone - seminal plasma
66
biomnis test list
test name
amineptine - serum
amiodarone - serum
amisulpride - serum
amitriptyline - serum
amoebiasis - serology - serum
amoxapine - serum
amoxicillin - serum
amphetamines - confirmation - serum
amphetamines - confirmation - urines
amphetamines - screening - urines
amprenavir - plasma
amylase - aspiration biopsy
amylase – macro – serum
amylase - pancreatic and salivary isoenzymes - serum
androstenediol - urine
angiostrongylus cantonensis - serology - serum
anti-21-hydroxylase antibodies - serum
anti-actin antibodies - screening - serum
anti-actin antibodies - titration - serum
anti-annexin v antibodies - igg - serum
anti-biliary canal antibodies - serum
anti-bp180 antibodies - serum
anti-c1q antibodies - serum
67
biomnis test list
test name
anti-calcium channel antibodies - serum
anti-c antibodies - mass dosage
anticoagulant protein c - activity - plasma
anticoagulant protein c - antigen - plasma
anticoagulant protein s - activity - plasma
anti-cochlear antibodies - serum
anti-d antibodies passives administered after delivery - serum
antidepressants - screening - identification - dosage - serum
antidepressants - screening - identification - dosage - urines
anti-desmoglein antibodies - serum
anti-dna antibodies denatured - ssdna - serum
anti-dna antibodies native - farr test - serum
anti-dna antibodies native - ifi - serum
anti-epidermal antibodies - serum
anti-ethinyloestradiol antibodies - serum
anti-exocrine pancreas antibodies - serum
anti-eye antibodies - serum
anti-factor ix antibodies - screening - plasma
anti-factor ix antibodies - titration - plasma
anti-factor vii antibodies - screening - plasma
anti-factor viii antibodies - screening - plasma
anti-factor viii antibodies - titration - plasma
anti-glycolipid antibodies - csf
68
biomnis test list
test name
anti-glycolipid antibodies - serum
anti-gp210 antibodies - serum
anti-histone antibodies - serum
anti-hla antibodies - serum
anti-intestinal antibodies - enterocytes - serum
anti-keratin antibodies - serum
anti-lactoferrin and anti-carbonic anhydrase antibodies - serum
anti-mitochondrial antibodies - type 5 - serum
anti-mitochondrial antibodies - typing - serum
anti-musk antibodies - serum
anti-myocardium antibodies - serum
anti-neuromyelitis optica antibodies - serum
anti-neuron antibodies - csf
anti-neuron antibodies - serum
anti-nucleosome antibodies - serum
antioxidant activity - plasma
anti-oxidised ldl antibodies - igg and/or igm - serum
anti-parathyroid antibodies - serum
anti-pf4 antibodies - heparin - plasma
anti-phosphatidylethanolamine antibodies - igg - serum
anti-phosphatidylethanolamine antibodies - igm - serum
anti-phosphatidylinositol antibodies - igg - serum
anti-phosphatidylserine antibodies - igg - serum
69
biomnis test list
test name
anti-pituitary antibodies - serum
anti-platelet antibodies bound - identification - whole blood
anti-platelet antibodies bound - screening - whole blood
anti-potassium channel antibodies - serum
anti-progesterone antibodies - serum
anti-prothrombin antibodies - igg - serum
anti-ribosome antibodies - serum
anti-salivary gland antibodies - serum
anti-sp100 antibody - igg - serum
anti-staphylolysin - asta - serum
antistreptodornase b - asd b - serum
antistreptokinase - ask - serum
antistreptolysin - aslo - serum
anti-synthetase (mi-2, ku, pl-7, pl-12), anti-srp and anti-pmscl antibodies - serum
anti-t3 antibodies - triiodothyronine - serum
anti-t4 antibodies - thyroxine - serum
anti-testicular antibodies - serum
antithrombin - antigen - plasma
antithrombin - functional activity - plasma
anti-tissue antibodies - screening and titration of kidney-liver-stomach - serum
anti-titin antibodies - serum
anti-tubular basement membrane antibody - serum
anti-type ii collagen antibodies - serum
70
biomnis test list
test name
anti-tyrosine phosphatase antibodies - ia-2 - serum
anti-xa activity : danaparoid - orgaran - plasma
anti-xa activity : fondaparinux - arixtra - plasma
anti-xa activity : low molecular weight heparin - lmwh - plasma
anti-yop antibodies - serum
apolipoprotein c3 - serum
apolipoprotein e - serum
arginine - plasma
arginine - urines
arsenic - hair specimen
arsenic - nails
arsenic - plasma
arsenic - urines
ascariasis - serology - serum
asparagine - plasma
asparagine - urines
aspartic acid - plasma
aspartic acid - urines
aspergillosis - confirmation serology - serum
aspergillosis - screening serology - serum
aspergillus fumigatus - soluble antigen - testing - serum
atazanavir - plasma
avium-intracellular complex - direct diagnosis - pcr/nasba
71
biomnis test list
test name
baclofene - serum
barbiturates - urines
barium - urines
bartonellosis - b. henselae - b. quintana - igg serology - serum
bartonellosis - direct diagnosis - pcr
bcr-abl - gene - quantitative - whole blood
benzene - whole blood
benzodiazepines - identification - dosage - serum
benzodiazepines - screening without identification - serum
benzodiazepines - screening without identification - urines
beryllium - urines
beta-2 microglobulin - aspiration biopsy
beta-2 microglobulin - csf
beta-2 microglobulin - urine
beta-2 transferrin
beta-alanine - plasma
beta-alanine - urines
beta-aminobutyric acid - plasma
beta-aminobutyric acid - urines
bile acids - chromatography - serum
bile pigments - urines
bilirubin indirect - free or non-conjugated - serum
biotinidase - serum
72
biomnis test list
test name
anti-tyrosine phosphatase antibodies - ia-2 - serum
anti-xa activity : danaparoid - orgaran - plasma
anti-xa activity : fondaparinux - arixtra - plasma
anti-xa activity : low molecular weight heparin - lmwh - plasma
anti-yop antibodies - serum
apolipoprotein c3 - serum
apolipoprotein e - serum
arginine - plasma
arginine - urines
arsenic - hair specimen
arsenic - nails
arsenic - plasma
arsenic - urines
ascariasis - serology - serum
asparagine - plasma
asparagine - urines
aspartic acid - plasma
aspartic acid - urines
aspergillosis - confirmation serology - serum
aspergillosis - screening serology - serum
aspergillus fumigatus - soluble antigen - testing - serum
atazanavir - plasma
avium-intracellular complex - direct diagnosis - pcr/nasba
73
biomnis test list
test name
biperiden - serum
bird-breeder s lung - confirmation - serum
bird-breeder s lung - screening - serum
blastomycosis - serology - serum
b-lph - beta-lipotropin - plasma
boron - serum
boron - urines
borreliosis - direct diagnosis - pcr
borreliosis - screening serology - aspiration biopsy
borreliosis - screening serology - csf
botulic toxin - serum
bromazepam - serum
bromine - serum
bromine - urines
bupivacaine - serum
buprenorphine and metabolites - urines
buprenorphine - serum
butoxyacetic acid - urines
c1-inhibitor - complement fraction - functional + quantitation
c1-inhibitor - complement fraction - quantitation - serum
c1q - complement fraction - serum
c2 - complement fraction - serum
c3 - complement fraction - aspiration biopsy
74
biomnis test list
test name
c3nef - nephritic factor - serum
c4b-bp - complement fraction - plasma
c4 - complement fraction - aspiration biopsy
c5 - complement fraction - serum
c9 - complement fraction - serum
ca 125 antigen - aspiration biopsy
ca 15-3 antigen - aspiration biopsy
ca 19-9 antigen - aspiration biopsy
ca 50 antigen - aspiration biopsy
ca 50 antigen - serum
ca 72-4 antigen - aspiration biopsy
cadmium - urines
caffeine - serum
calculi - morphologic and infrared analysis - calculus
calprotectin - stool
campylobacter - screening
campylobacter - serology - serum
candida - soluble antigens - serum
cannabis - confirmation - serum
cannabis - confirmation - urines
cannabis - urines
carbohydrate-deficient transferrin - serum
carboxyhaemoglobin - whole blood
75
biomnis test list
test name
carnitine free and total - urine
carotenoids - serum
carpipramine - serum
cbg - cortisol-binding globulin - transcortin - serum
cea - carcinoembryonic antigen - aspiration biopsy
cefepime - serum
cefixime - serum
cefotaxime - serum
ceftazidime - serum
ceftriaxone - serum
celiprolol - serum
ch50 - total haemolytic complement - aspiration biopsy
cheese-washer s lung - screening - serum
chikungunya - igg serology - serum
chikungunya - igm serology - serum
chlamydia pneumoniae - direct diagnosis - pcr
chlamydia pneumoniae - igg/igm serology - serum
chlamydia psittaci - iga serology - serum
chlamydia psittaci - igg/igm serology - serum
chlordiazepoxide - serum
chlorophenol - urines
chloroquine - serum
chlorpromazine - serum
76
biomnis test list
test name
cholera - screening - stool
chromium - urines
chromium - whole blood
chromogranin a - serum
chromosomal rearrangement - characterisation - fish
chromosomal rearrangement - characterisation - fish - whole blood
chylomicrons - screening - biological fluid
chymotrypsin - stool
cibenzoline - serum
ciprofloxacin - serum
circulating anticoagulant - screening - plasma
circulating immune complexes - cic - serum
cisplatin - serum
citalopram - serum
citric acid - seminal plasma
citric acid - serum
citric acid - urines
citrulline - plasma
citrulline - urines
class ii hla - hla-dq and hla-dr genotyping - whole blood
clindamycin - serum
clobazam - serum
clomipramine - serum
77
biomnis test list
test name
clonazepam - serum
clorazepate - serum
clostridium difficile - toxins a and b - screening - stool
clostridium perfringens - pcr - stool
clotiazepam - serum
cloxacillin - serum
clozapine - serum
cobalt - urines
cobalt - whole blood
cocaine - confirmation - serum
cocaine - confirmation - urines
cocaine - screening - urines
coccidioidomycosis - serology - serum
coenzyme q10 - coq10 - serum
colchicine - serum
cold agglutinins - screening
cold agglutinins - titration
colistin - serum
connexin 26 - gene - whole blood
corticosterone - compound b - serum
cortisol - compound f - saliva
cortisol - compound f - serum
cortisone - compound e - plasma
78
biomnis test list
test name
cortisone - compound e - urine
cotinine - urines
creatorrhoea - faecal nitrogen dosage - stool
crosslaps - serum
crosslaps - urines
crp - c-reactive protein - ultrasensitive - serum
cryofibrinogen - plasma
cryoglobulins - identification - serum
cryoglobulins - screening - serum
cryptococcus neoformans - soluble antigen - testing
cryptococcus neoformans - soluble antigen - titration
cryptosporidia - screening - stool
cyamemazine - serum
cyanides - ion cn- - whole blood
cyclic amp nephrogenic
cyclic amp - plasma
cyclic amp - urine
cyclohexanol - urines
cyfra 21-1 antigen - aspiration biopsy
cyfra 21-1 antigen - serum
cystathionine - plasma
cystathionine - urines
cysticercosis - confirmation serology - serum
79
biomnis test list
test name
cysticercosis - serology - serum
cystine - plasma
cytomegalovirus - cmv - antibody avidity - serum
cytomegalovirus - cmv - direct diagnosis - pcr - amniotic fluid
cytomegalovirus - cmv - igg serology - csf
cytomegalovirus - cmv - orientated culture - rapid and conventional culture
cytomegalovirus - cmv - presumptive diagnosis
cytomegalovirus - cmv quantification - direct diagnosis pcr - whole blood
d4a - delta-4-androstenedione - serum
darunavir - plasma
dcp - decarboxy prothrombin - plasma
demodex - screening
dengue fever - igg and/or igm serology - serum
dengue fever - igm serology - serum
density - urines
deoxypyridinoline - urines
desipramine - serum
dexamethasone - serum
dextropropoxyphene - serum
dextropropoxyphene - urines
dhea - dehydroepiandrosterone - urines
dht - dihydrotestosterone - serum
diazepam + desmethyldiazepam - serum
80
biomnis test list
test name
dibekacin - serum
dichloromethane - urines
dichloromethane - whole blood
didanosine - plasma
diltiazem - serum
dilute russell s viper venom time - plasma
diphtheria - immunity test - igg serology - serum
diphtheria - screening
direct ldl cholesterol - serum
disopyramide - plasma
distomatosis - confirmation serology - serum
distomatosis - screening serology - serum
diuretics - screening and dosage - urines
dosulepin - serum
doxepin - serum
doxycycline - serum
dropingeridol - serum
ecp - eosinophil cationic protein - serum
efavirenz - plasma
elastase - stool
electrolytes stool - stool
emtricitabine - plasma
enfuvirtide - plasma
81
biomnis test list
test name
enterohaemorrhagic escherichia coli - antigen identification
enterovirus - direct diagnosis - pcr - csf
eosinophils - screening - plasma
epstein-barr virus - ebv - direct diagnosis - pcr
epstein-barr virus - ebv - vca igg, ebna, igg serology - csf
epstein-barr virus - ebv - vca igg, ebna, igg serology - serum
epstein-barr virus - ebv - vca igm serology - serum
erythrocyte cholinesterase - whole blood
erythrocyte copper - whole blood
erythrocyte direct coombs - whole blood
erythrocyte ferritin - whole blood
erythrocyte folic acid
erythrocyte glutathione peroxidase - whole blood
erythrocyte iron - whole blood
erythrocyte lithium - whole blood
erythrocyte magnesium - whole blood
erythrocyte metformin - whole blood
erythrocyte porphyrins - whole blood
erythrocyte potassium - whole blood
erythrocyte pyruvate kinase - whole blood
erythrocyte transketolase - whole blood
estazolam - serum
ethanolamine - plasma
82
biomnis test list
test name
ethosuximide - serum
ethoxyacetic acid - urines
ethylene glycol - serum
etravirine - plasma
everolimus - whole blood
exotic fungus - screening - various specimen
extended phenotype - whole blood
factor b - complement fraction - serum
factor i - fibrinogen - antigen - plasma
factor v leiden - p.arg506gln mutation - whole blood
factor v - proaccelerin - plasma
factor xi - rosenthal - plasma
faecal test -functional coprology - stool
farmer s lung - confirmation - serum
farmer s lung - screening - serum
fatty acids free non-esterified - serum
fatty acids with long chains - c14 to c22 - plasma
fatty acids with very long chains - c22 to c26 - plasma
felbamate - serum
ferritin glycosylated - serum
fibromax
fibrometer
fibronectin
83
biomnis test list
test name
fibrotest - actitest - serum
filariasis - screening - whole blood
filariasis - serology - serum
flecainide - serum
fluconazole - serum
flucytosine - serum
flunitrazepam - serum
fluorine - serum
fluorine - urines
fluoxetine - serum
flupentixol - serum
fluphenazine - serum
fluvoxamine - serum
formic acid - urines
fosamprenavir - plasma
fosfomycin - serum
fragile x - fraxa site - triplet repeat expansion of the fmr1 gene
fragile x - fraxa site - triplet repeat expansion of the fmr1 gene - whole blood
fragments 1+2 - prothrombin - plasma
free anticoagulant protein s - antigen - plasma
free cortisol - compound f - urines
free trichloroethanol - whole blood
fructosamine - serum
84
biomnis test list
test name
fsh - follicle-stimulating hormone - urines
furosemide - serum
furosemide - urines
fusidic acid - serum
gabapentin - serum
galactose-1-phosphate uridyl transferase - blotting paper
gamma-aminobutyric acid - plasma
gamma-aminobutyric acid - urines
ganciclovir - plasma
gene rearrangements, deletion, amplification - solid tumors - fish
ghrh - growth-hormone-releasing-hormone - plasma
glucagon - plasma
glutamic acid - plasma
glutamic acid - urines
glutamine - plasma
glutamine - urines
glutathione peroxidase - plasma
glycine - plasma
glycine - urines
glycosaminoglycanes - gag - electrophoresis - urine
glycosaminoglycanes - gag - urine gag/creatinine ratio - urine
gnathostomiasis - serology - serum
gonococcus - serology - serum
85
biomnis test list
test name
haemoglobin free - serum
haemoglobin paroxysmal nocturnal - pnh - whole blood
haemoglobin - screening for anomalies - whole blood
haemolysis protein profile - serum
haemopexin - serum
haemophilus ducreyi - screening
haemophilus influenzae b - serology - serum
haemorrhagic fever with renal syndrome - hfsr - igg/igm serology - serum
haloperidol - serum
haloperidol - urines
hcg - whole molecule - biological fluid
hcg - whole molecule - serum
hdl2/hdl3 cholesterol - serum
helicobacter pylori - 13c urea breath test - expired gas
helicobacter pylori - 13c urea breath test - expired gas
helicobacter pylori - culture - biopsy
heparin cofactor ii - plasma
hepatitis b - pre-s1 antigen - serum
hepatitis b - ymdd mutation - serum
hepatitis c - control serology - serum
hepatitis c - riba - serum
hepatitis delta - antigen - serum
hepatitis delta - total antibodies - serum
86
biomnis test list
test name
hepatitis delta - viral rna - serum
hepatitis e - igg antibody - serum
hepatitis e - viral rna detection - pcr - serum
hepatitis e - viral rna detection - pcr - stool
hepatitis g - viral rna - serum
her2 - human epidermal growth factor receptor 2 - c-erbb-2 protein - serum
her2 - human epidermal growth factor receptor 2-status-invasive breast tumors-fish
herpes gestationis factor/anti-bp180 - serum
herpes simplex virus 1/2 - hsv - igg serology - csf
herpes simplex virus 1/2 - hsv - orientated culture
herpes simplex virus 1/2 - hsv - presumptive diagnosis
herpes virus type 6 - igg serology (igm on specific request) - serum
herpes virus type 6 - viral dna detection - pcr - whole blood
herpes virus type 8 - igg serology (igm on specific request) - serum
herpes virus type 8 - viral dna detection - pcr
high-resolution karyotype - whole blood
hippuric acid - urines
histamine - plasma
histamine release - whole blood
histamine - whole blood
histidine - plasma
histidine - urines
histoplasmosis - serology - serum
87
biomnis test list
test name
hiv1 - human immunodeficiency virus - proviral dna - whole blood
hiv1 - human immunodeficiency virus - viral load - plasma
hiv - human immunodeficiency virus - genotype : antiviral resistance profile - plasma
hiv - human immunodeficiency virus - p24 antigen - serum
holotranscobalamin - serum
homocystine - urines
homogentisic acid - urines
homovanillic acid - urines
htlv i/ii - confirmation serology - serum
htlv i/ii - proviral dna - whole blood
htlv i/ii - screening serology - serum
human babesiosis - serology - serum
human ehrlichiosis - serology - serum
human placental lactogen - hpl - serum
hyaluronic acid - pleural fluid
hyaluronic acid - serum
hydroquinidine - serum
hydroxychloroquine - whole blood
hydroxylysine - urines
hydroxyproline - plasma
hydroxyproline - total + free - urine
hydroxyproline - urines
hydroxyzine - serum
88
biomnis test list
test name
hypodermosis - confirmation serology - serum
hypodermosis - screening serology - serum
hypoxanthine - urine
ibuprofen - serum
iga - immunoglobulin a - aspiration biopsy
iga - immunoglobulin a - iga1/2 subclasses - serum
iga - immunoglobulin a - saliva
iga - immunoglobulin a - urine
igf-1 - somatomedin c - serum
igg - immunoglobulins g - aspiration biopsy
igg - immunoglobulins g - csf
igg - immunoglobulins g - urine
igm - immunoglobulins m - aspiration biopsy
igm - immunoglobulins m - csf
igm - immunoglobulins m - urine
imipenem - serum
imipramine - serum
immunity protein profile without electrophoresis - serum
immunoallergic heparin-induced thrombopaenia - functional test
immunobinding - serum
immunoreactive trypsin - blotting paper
immunoreactive trypsin - serum
indinavir - plasma
89
biomnis test list
test name
indirect antiglobulin test - iat - screening/identification
inflammatory protein profile - serum
influenza - orientated culture
influenza - presumptive diagnosis
inh - isoniazid and acetylation test - serum
interferon alpha - biological fluid
interferon alpha - csf
interferon alpha - neutralizing antibody - serum
interferon alpha - serum
interferon beta - neutralizing antibody - serum
interferon gamma - csf
interferon gamma - serum
interleukin (il)-1 beta - serum
interleukin (il)-2 - receptor - serum
interleukin (il)-2 - serum
interleukin (il)-4 - serum
interleukin (il)-5 - serum
interleukin (il)-6 - receptor - serum
interleukin (il)-6 - serum
interleukin (il)-8 - serum
iodine total - serum
iodine - urines
iron - saturation percentage - serum
90
biomnis test list
test name
iron - urines
isepamicin - serum
isoelectric focussing
isoleucine - plasma
isoleucine - urines
itraconazole and hydroxylated metabolite - serum
kappa free light chains - serum
kappa free light chains - urine
ketoconazole - serum
kleihauer test - whole blood
lactic acid - csf
lactic acid - plasma
lambda free light chains - serum
lambda free light chains - urine
lamivudine + abacavir - plasma
lamivudine - plasma
lamotrigine - serum
laxatives - screening - stool
ldh - lactate dehydrogenase - aspiration biopsy
legionellosis - direct diagnosis - pcr
legionellosis - lp1 antigen - urines
legionellosis - serogroups 1 to 6 - confirmation serology - serum
legionellosis - serogroups 1 to 6 - screening serology - serum
91
biomnis test list
test name
leishmaniasis - direct diagnosis - pcr
leishmaniasis - screening
leptin - serum
leptospirosis - 9 antigens serology - martin-pettit - serum
leptospirosis - dna detection - pcr
leptospirosis - serology - serum
leucine aminopeptidase - serum
leucine - plasma
leucine - urines
levetiracetam - serum
levofloxacin - serum
levomepromazine - serum
lh - luteinising hormone - urines
lidocaine - serum
lipase - aspiration biopsy
lipase - urines
lipoprotein lp(a-i) - serum
lipoproteinogram - serum
lopinavir - plasma
loprazolam - serum
lormetazepam - serum
loxapine - serum
lsd - lysergic acid diethylamide - urines
92
biomnis test list
test name
ltt - lymphoblast transformation test - whole blood
lymphocytes - lymphocyte proliferation typing
lymphocytic choriomeningitis - serum
lysine - plasma
lysine - urines
lysozyme - serum
lysozyme - urine
malassezia furfur - screening
malondialdehyde - plasma
mandelic acid - urines
manganese - urines
manganese - whole blood
maprotiline - serum
measles - igg serology - csf
mefloquine - serum
melatonin - plasma
melatonin - urine
mepivacaine - serum
meprobamate - serum
meprobamate - urines
mercury - hair specimen
mercury - saliva
mercury - urines
93
biomnis test list
test name
mercury - whole blood
metformin - serum
methadone - screening - urines
methadone - serum
methaemoglobin - whole blood
methaqualone - serum
methionine - plasma
methionine - urines
methotrexate - serum
methoxyacetic acid - urines
methoxylated derivatives of catecholamines - plasma
methoxylated derivatives of catecholamines - urines
methyl alcohol - serum
methyl ethyl ketone - urines
methylhippuric acid - urines
methyl isobutyl ketone - urines
methylmalonic acid - plasma
methylmalonic acid - urines
metoclopramide - serum
metoprolol - serum
mevalonic acid - urines
mianserin - serum
microsporidia - screening - stool
94
biomnis test list
test name
midazolam - serum
milnacipran - serum
minocycline - serum
mirtazapine - serum
moclobemide - serum
molybdenum - plasma
molybdenum - urines
mumps - igg serology - csf
mumps - orientated culture
mycobacteria - anti-a60-antigen-antibodies - igg serology - serum
mycobacteria atypical - identification
mycobacteria - culture - hospital infection control
mycobacteria - direct examination
mycobacteria - susceptibility testing
mycobacterium tuberculosis - identification
mycophenolate - plasma
mycoplasma pneumoniae - direct diagnosis - pcr
myelogram
naropeine - serum
nelfinavir - plasma
neopterin - csf
neopterin - serum
neopterin - urines
95
biomnis test list
test name
nesdonal - serum
netilmicin - serum
nevirapine - plasma
niaprazine - serum
nickel - serum
nickel - urines
nitrazepam - serum
n-methylformamide - urines
norandrolone - serum
norandrolone - urine
nordazepam - serum
nordin - index - urines
nordin - index - with hydroxyproline - urines
nortriptyline - serum
nse - neuron-specific enolase - aspiration biopsy
nse - neuron-specific enolase - csf
nt-probnp - n-terminal pro-brain natriuretic peptide - serum
ntx - n-telopeptides of type i collagen - urines
nutritional protein profile - serum
o-cresol - urines
oestradiol - biological fluid
oestradiol - urines
oestradiol - woman - serum
96
biomnis test list
test name
oestrone - serum
ofloxacin - serum
olanzapine - serum
opiates - confirmation - serum
opiates - confirmation - urines
opiates - screening - urines
oral anticoagulants : fluindione - serum
oral anticoagulants : rodenticides - serum
organic acids - urine
ornithine - plasma
ornithine - urines
orosomucoid - serum
orotic acid - urines
osmolarity - osmolality - aspiration biopsy
osmolarity - osmolality - stool
osmotic globular resistance - whole blood
oxacillin - serum
oxalic acid - serum
oxazepam - serum
oxcarbamazepine - serum
p1np - intact n-terminal propeptide of type i procollagen - serum
pai1 - plasminogen activator inhibitor-1 - plasma
pancreatic polypeptide - plasma
97
biomnis test list
test name
pancreatic polypeptide - plasma
paracetamol - serum
parainfluenzae 1, 2, 3 - presumptive diagnosis
parainfluenzae 1, 2, 3 - serology - serum
paraquat - serum
paraquat - urines
paroxetine - serum
parvovirus b19 - direct diagnosis - pcr - amniotic fluid
pasteurelloses - serology - serum
paul-bunnell-davidsohn - pbd - heterophile antibodies - serum
pca3 - gene - prostate cancer marker - messenger rna detection
pefloxacin - serum
pentachlorophenol - urines
pertussis - direct diagnosis - pcr
pertussis - presumptive diagnosis
pertussis - serology - serum
pesticides - screening and/or dosage - serum
pesticides - screening and/or dosage - urines
phencyclidine - screening - urines
phencyclidine - serum
phenol - urines
phenothiazines - serum
phenothiazines - urines
98
biomnis test list
test name
phenylalanine - blotting paper
phenylalanine - plasma
phenylalanine - urines
phenylglyoxylic acid - urines
phosphorus - tubular reabsorption rate
phosphorus - urines
phosphoserine - plasma
phosphoserine - urines
physical analysis - stool
physical and chemical analysis - stool
phytanic acid - plasma
picornavirus - serology - serum
pimozide - serum
pipamperone - serum
piperacillin - serum
pipothiazine - serum
plasminogen - plasma
platelet typing - whole blood
platinum - serum
pneumococcus - capsular polysaccharide - serology - serum
pneumocystis pneumonia - p. jirovecii - screening
p-nitrophenol - urines
poliovirus - serology - serum
99
biomnis test list
test name
polyomavirus bk - viral dna detection - pcr
polyomavirus jc - viral dna detection - pcr - csf
porphobilinogen - urines
porphyrins - urines
ppz - zinc protoporphyrin - whole blood
prazepam - serum
prealbumin - serum
precipitins - confirmation - serum
precipitins - screening - serum
prednisolone - serum
pregnandiol - urines
pregnanetriol - urine
pregnenolone - serum
pregnenolone sulfate - serum
prekallikrein - activity - plasma
primidone - serum
procalcitonin - serum
proinsulin - serum
prolactin - molecular forms - serum
prolactin - serum
proline - plasma
proline - urines
promethazine - serum
100
biomnis test list
test name
propafenone - serum
propranolol - serum
protein 14.3.3 - csf
protein electrophoresis - tears
protein electrophoresis - urine
protein immunoelectrophoresis - urine
protein profile for screening without electrophoresis - serum
protein s100 - serum
protein thiols - plasma
psa - prostate-specific antigen total - aspiration biopsy
pseudomonas aeruginosa - anti-exotoxin a antibodies - serum
pth - intact parathormone - aspiration biopsy
pth - intact parathormone - serum
pth-rp - parathormone related protein - plasma
pyruvic acid
quinidine - serum
quinine - serum
rabies - serology - serum
raltegravir - plasma
renin active - plasma
reptilase clotting time - plasma
respiratory syncytial virus - rsv - culture
retinol-binding protein - rbp - serum
101
biomnis test list
test name
rhesus d - foetal genotype - whole blood
rhesus kell - phenotype - whole blood
rheumatoid factors - aspiration biopsy
ribavirin - plasma
rickettsioses - r. conorii, r. typhi - serology - serum
rickettsioses - r. conorii - serology - serum
rickettsioses - r. helvetica - serology - serum
rickettsioses - r. prowazeki - serology - serum
rickettsioses - r. slovaca and r. africae - spotted fever group - serum
rickettsioses - r. typhi - serology - serum
rifabutin - plasma
rifampicin - serum
risperidone - serum
ritonavir - plasma
rotavirus - serology - serum
rt3 - reverse triiodothyronine - serum
rubella - antibody avidity - igg - serum
rubella - direct diagnosis - pcr - amniotic fluid
salmonellosis - antigen identification
salmonellosis - serology - serum
saquinavir - plasma
scc-ta4 antigen - aspiration biopsy
scc-ta4 antigen - serum
102
biomnis test list
test name
schistosomiasis - egg screening - urines
scrub typhus - orientia tsutsugamushi - serology - serum
selenium - serum
selenium - urines
serine - plasma
serine - urines
serotonin - urine
serotonin - whole blood
sertraline - serum
serum amyloid a protein - saa - serum
sézary cells - screening - smear
shigellosis - serology - serum
silicon - plasma
silver - plasma
silver - urines
sirolimus - whole blood
soluble bacterial antigens
soluble bacterial antigens - pneumococcus - urines
soluble complexes - plasma
soluble tnf-alpha receptor - stnf-ri - p55 - plasma
soluble tnf-alpha receptor - stnf-ri - p75 - plasma
soluble transferrin receptor - serum
somatostatin - plasma
103
biomnis test list
test name
specific ige : ammonium iv - curare - serum
specific ige : hymenoptera venom - single allergen - serum
specific ige : inhalant allergen testing - phadiatop® - serum
specific ige : latex - single allergen - serum
specific ige : medicines - single allergen - serum
specific ige : other medicines - single allergen - serum
specific igg4 - serum
sperm - dna fragmentation - scsa - sperm
sry - gene - study
stavudine - plasma
steatorrhoea - fat dosage - stool
steroid profile - urine
strongyloidiasis - screening - baermann method - stool
strongyloidiasis - serology - serum
strontium - plasma
strychnin - whole blood
styrene - urines
styrene - whole blood
sugars - chromatography - urines
sulfocysteine - plasma
sulfocysteine - urines
sulphonylurea - urine
sulpiride - serum
104
biomnis test list
test name
sultopride - serum
superoxide dismutase - sod - whole blood
syphilis - igg confirmation serology - serum
syphilis - igm confirmation serology - serum
syphilis - igm serology - serum
syphilis - quantitative serology - serum
syphilis - screening serology - serum
t3 - triiodothyronine - urines
t4 - thyroxine - urines
tacrolimus - fk-506 - whole blood
tati - tumour-associated trypsin inhibitor - serum
taurine - plasma
taurine - urines
tazocilline - serum
teicoplanin - serum
temazepam - serum
tenofovir - plasma
testosterone bioavailability - serum
testosterone - urines
tetanus - immunity test - igg serology - serum
tetrachloroethylene - urines
tetrachloroethylene - whole blood
tetrachloromethane - whole blood
105
biomnis test list
test name
tetrazepam - serum
thiocyanates - ion - serum
thiocyanates - ion - urines
thioridazine - serum
threonine - plasma
threonine - urines
thrombin clotting time - plasma
thymidine kinase - serum
thyroxine-binding globulin - tbg - serum
tianeptine - serum
tiapride - serum
ticarcillin - serum
tick-borne encephalitis - tbe - igg/igm serology - serum
tin - plasma
tin - urine
tipranavir - plasma
tissue plasminogen activator - antigen - plasma
titanium - plasma
tnf-alpha - tumour necrosis factor - serum
tobramycin - serum
toluene - urines
toluene - whole blood
topiramate - serum
106
biomnis test list
test name
total anticoagulant protein s - antigen - plasma
total ige - tears
total lipids - biological fluid
total lipids - urines
total t3 - total triiodothyronine - serum
total t4 - total thyroxine - serum
toxocariasis - confirmation serology - serum
toxocariasis - serology - serum
toxoplasmosis - antibody avidity - igg - serum
toxoplasmosis - immune load - serum
toxoplasmosis - pcr - amniotic fluid
toxoplasmosis - viral dna detection - pcr
toxoplasmosis - western blot
tpa - tissue polypeptide antigen - serum
tramadol - serum
transcobalamins - serum
trans-muconic acid - ttma - urines
treponema - direct examination
triazolam - serum
trichinosis - confirmation serology - serum
trichinosis - igg serology - serum
trichloroacetic acid + trichloroethanol - tce + tca - urines
trichloroacetic acid - urines
107
biomnis test list
test name
trichloroethylene - whole blood
trichloromethane - whole blood
trichogramma
trihexyphenidyl - serum
trimethoprim - serum
trimipramine - serum
trisomy 21 - maternal serum markers - serum
tropheryma whippelii - bacterial dna detection - pcr
trypanosoma cruzi - serology - serum
trypanosoma gambiense - serology - serum
trypanosoma - screening - whole blood
tryptase - serum
tuberculosis complex - direct diagnosis - pcr/nasba
tuberculosis complex - isoniazid resistance - katg and inha
tuberculosis complex - rifampicin resistance - rpob
tularemia - francisella tularensis - serology - serum
type iii procollagen - serum
tyrosine - plasma
tyrosine - urines
uniparental disomy - upd
uniparental disomy - upd - whole blood
urobilinogen - urines
urogenital mycoplasmas - culture
108
biomnis test list
test name
urogenital mycoplasmas - serology - serum
valine - plasma
valine - urines
vanadium - urines
vancomycin - serum
varicella zoster virus - igg serology - csf
varicella zoster virus - orientated culture
varicella zoster virus - presumptive diagnosis
varicella zoster virus - viral dna detection - pcr
varicella zoster virus - viral dna detection - pcr - amniotic fluid
venlafaxine - serum
verapamil - serum
vigabatrin - serum
viloxazine - serum
vip - vasoactive intestinal polypeptide - plasma
viral antibody screen - screening - serum
virus isolation - non orientated culture
vitamin b8 or h - biotin - serum
vitamin c - ascorbic acid - plasma
vitamin k1 - phylloquinone - serum
vitamin pp - niacin - whole blood
von willebrand factor antigen + factor viii coagulation activity and ristocetin cofactor activities
- plasma
voriconazole - plasma
109
biomnis test list
test name
water free - clearance
west nile virus - igg/igm serology - serum
xanthine - urine
xylenes - urines
xylenes - whole blood
xylose - plasma
xylose - urines
yellow fever - immunity test - serum
yersinia - screening - stool
yersinia - serology - serum
zidovudine - plasma
zinc erythrocytes - whole blood
zinc - sperm
zolpidem - serum
zonisamide - serum
zopiclone - serum
zuclopenthixol - serum
zygosity - twinning study
110
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