انت هنا الان : شبكة جامعة بابل > موقع الكلية > نظام التعليم الالكتروني > مشاهدة المحاضرة
الكلية كلية الصيدلة
القسم فرع الكيمياء
المرحلة 3
أستاذ المادة اميرة محمد علي جاسم حمادي
5/12/2011 9:05:30 AM
The Role of Iron in Diabetes mellitus
Because iron participates in the formation of reactive oxygen species, organisms take great care in the handling of iron and, indeed, iron sequestration in transport and storage proteins may contribute to antioxidant defenses. It is now well established that oxidants can cause release of catalytic iron , thus initiating a vicious cycle that leads to the formation of more reactive oxygen species , iron salts play catalytic role in a reaction commonly referred to as the metal-catalyzed Haber- Weiss reaction (1) .
Fe 3+ + Oـــ2 Fe 2+ + O2
Fe 2+ + H2 O2 Fe 3+ + OH + OH-
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Oـــ2 + H2 O2 O2 + OH + OH ــ
In this review we will discuss the role of tissue iron and elevated body iron stores in causing type 2 diabetes as well as the pathogenesis of its important complications, particularly diabetic nephropathy and cardiovascular (CV) disease. In addition, we emphasize that iron overload is not a prerevquisite for iron to mediate either diabetes or it complications. Important in its pathophysiology is the availability of so- called catalytic iron or iron that is available to participate in free-radical reactions.
Role of Iron in Induction of Diabetes Mellitus
The evidence that systemic iron overload could contribute to abnormal glucose metabolism was first derived from the observation that the freqeiçy of diabetes is increased in classic hereditary hemochromatosis (HH). However, with the discovery of novel genetic disorders of iron metabolism, it is obvious that iron irrespective of the cause or the gene involved, results in increased role of iron in the pathogenesis of diabetes mellitus is suggested by (1) an increased incidence of type 2 diabetes mellitus. The incidence of type 2 diabetes mellitus in diverse causes of iron overload and (2) reversal or improvement in diabetes (glycemic control), with reduction in iron load achieved using either phlebotomy or iron chelation therapy
Recently a link has been established between increased dietary iron intake, particularly with eating red meat, with increased body iron stores and the development of diabetes. A causatjve link with iron overload is suggested by the improvement in insulin sensitivity and insulin secretion with frequent blood donation and decreased iron in stores .
المادة المعروضة اعلاه هي مدخل الى المحاضرة المرفوعة بواسطة استاذ(ة) المادة . وقد تبدو لك غير متكاملة . حيث يضع استاذ المادة في بعض الاحيان فقط الجزء الاول من المحاضرة من اجل الاطلاع على ما ستقوم بتحميله لاحقا . في نظام التعليم الالكتروني نوفر هذه الخدمة لكي نبقيك على اطلاع حول محتوى الملف الذي ستقوم بتحميله .
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