Abstract : Objective: The combination birth control pill of ethinyl estradiol with drospirenone
(YASMIN) is an effective contraceptive which used by a very large number of women
worldwide, and this study was designed to investigate the probable histological and
histochemical changes of the liver and kidney accompanied with the treatment by yasmin.
Methods: 12 females adult rabbits were used in this experiment (6 treated animals and 6 as
control group). The treatment by the yasmin contraceptive pills based on the same way as used
for women, regarding the body mass index for dosage, then frozen and ordinary tissue
sectioning were performed. Results: Histological and histochemical (for alkaline phosphatase –
ALP- activity) study of both liver and kidney was normal. Conclusion: Yasmin is safe with
regard to the histology of the liver and kidney, and the activity of ALP in these tissues.
Keywords: Yasmin, Histology and Histochemistry, Liver and Kidney, Rabbits.