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Abstract:
Behcet s disease (BD)
is a multigenertic inflammatory
systemic
disorder of unknown
etiology clinical featurr:s include oral and genital ulcers, ocular inflammation,
skin
lesions, as well as articular, vascular, neurological, pulmonary, gastrointestinal,
renal,
vascular and genitourinary
manifestations.
The main histopathological
finding is a widespread vasculitis of the arteries and
veins of any size. The cause of this disease is presumed
to be multifactorial involving
infectious triggers, genetic predisposirtion
and dysregulation
of the immune system.
Treatment of Behget dise,ase continues to be based largely on case reports,
case series,
and a few randomized
clinical trials.
lntroduction:
Behcet disease is a ch: onic inflammatory
systemic disorder, characterized
by a
Relapsing and remitting
course. It manifests with oral and genital urcerations, skin
lesions, uveitis, and vasct ar, central neryous system and gastrointestinal
involvement.
The main histopathological
finding is a widespread vasculitis of the arteries and
veins of any size. The dis;ease may staxt with one or more of the above symptoms but
other symptoms may gradually
appear .ver the years
[Arayssi and Hamdan
,2e04].
outside the eye, its course is characterized by recunent self-limiting episodesof
acute inflammation
that can lead to significant disability
[Sakane
et al. 199-9].
Ihe
disease burden ofBD is conhnedto, the early years (around
l5 years) ofits course,
and in many patients
the syndrome bums out over the years
[Kural-ieyahi
et ar.20031.
Major vessel disease and gentrar
nervous system (cNS)
involvement account for most
ofthe deaths seen in this condition andL can rarely appear for the first time rerativery
late in the course of the disease
[Kural_
!]eyahi et aI.20031.
As in most comple:{ diseases, troth genetic and environmental factors are
implicated
in the pathogenesis
of BD. HLA-B51 is by far the strongest associated
genetic factor reported in patients with BD compared with controls
[Remmers et al.
2010; Meguro et al. 2010;
de Menthon et al. 20091.

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